| EFFECTS OF THE HYPERTHERMIA AND HARRINGTONINE ON TELOMERASE ACTIVITY OF HL-60 CELLS |
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| 作者姓名： | 王宝燕 张海涛 李静 |
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| 作者单位： | Wang Baoyan，Zhang Haitao，Li JingDepartment of Hematology，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China. |
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| 基金项目： | ThisresearchwassupportedbytheScienceFoundationoftheFirstHospitalofXi’anJiaotongUniversity |
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| 摘 要： | ＴｅｌｏｍｅｒａｓｅｉｓａｎＲＮＡｄｅｐｅｎｄｅｎｔｐｏｌｙｍｅｒａｓｅｔｈａｔｓｙｎｔｈｅｓｉｚｅｓｔｒｌｏｍｅｒｅＴＴＡＧＧＧｒｅｐｅａｔｓｓｅｑｕｅｎｃｅｓａｔｔｈｅｅｎｄｓｏｆｃｈｒｏｍｏｓｏｍｅｓｒｅｑｕｉｒｅｄｆｏｒｔｈｅｉｎｔｅｇｒｉｔｙａｎｄｓｔａｂｉｌｉｔｙｏｆｌｉｎｅａｒｃｈｒｏｍｏｓｏｍｅｓ1] .Ｎｏｒｍａｌｓｏｍａｔｉｃｃｅｌｌｓ ,ｇｅｎｅｒａｌｌｙｌａｃｋｉｎｇｔｅｌｏｍｅｒａｓｅａｃｔｉｖｉｔｙ ,ｄｉｓｐｌａｙｐｒｏｇｒｅｓｓｉｖｅａｔｔｒｉｔｉｏｎｏｆｔｅｌｏｍｅｒ…
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EFFECTS OF THE HYPERTHERMIA AND HARRINGTONINE ON TELOMERASE ACTIVITY OF HL-60 CELLS |
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| Wang Baoyan,Zhang Haitao,Li Jing.EFFECTS OF THE HYPERTHERMIA AND HARRINGTONINE ON TELOMERASE ACTIVITY OF HL-60 CELLS[J].Academic Journal of Xi’an Jiaotong University,2002,14(1). |
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| Authors: | Wang Baoyan Zhang Haitao Li Jing |
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| Institution: | Department of Hematology, First Hospital of Xi'an Jiaotong University, Xi'an 710061,China. |
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| Abstract: | Objective To understand the mechanism of the hype rthermia and harringtonine in purging of leukemia cells In Vitro. telomerase activity of HL-60 cells treated by hyperthermia (42℃ for one hour) and di fferent concentrations of Harringtonine were investigated.Methods Using Telomeric Repeats Amplification Protocol (TRAP) a nd ELISA techniques to analyze the telomerase activity of HL-60 cells. Results Our results showed that harringtonine inhibited the tel omerase activity of HL-60 cells in a dosage related manner. Moreover, the telom erase activity of HL-60 cells was significantly decreased after the hyperthermi a treatment as compared with untreated cells.Conclusion The effect of the hyperthermia and Harringtonine on purging leukemia cells In Vitro may be mediated by down regulation of telome rase activity of tumor cells. |
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| Keywords: | telomerase HL-60 cells hyperthermia harringtonine |
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