西安地区32例北方汉族儿童HLA-DRDQ抗原分布状态的调查分析

我们调查了32例三代内无血缘关系的西安地区汉族健康儿童HLA-DR。DQ抗原分布状况。结果示除HLA-DR_1外,其它抗原频率与北京地区汉族人群HLA-DR,DQ抗原分布状态近似,但HLA-DR_1抗原频率在二者间的差别无统计学意义(Pc≥0.197)。与上海资料比较,二者间差别较大, 因样本例数较少,未作统计学处理。提示HLA-DR抗原在中国南北汉族人群间的分布状态有较明显的差别。与国内部分少数民族HLA-DR抗原分布状态相比较,与蒙古、朝鲜等北方少数民族HLA-DR抗原分布状态相接近。

INVESTIGATION ON DISTRIBUTION OF HLA-DR DQ ANTIGENS JN NORTH-CHINESE CHILDREN OF HAN NATIONALITY

The distribution of HLA antigens was investigated in 32 North-Chinese Han children aged 12～14 years, 20 of whom are male, the others are female. Except HLADR1, the frequencies of HLA-DR, DQ antigens in those children were almost identical to those in Han people in Beijing, but the difference of HLA-DR1 between the two groups was not significant statistically (Pc≥0.197). The difference of HLA-DR, DQ antigens between those children and Han people in Shanghai was obvious. This suggests that there is a differerce in distribution of HLA antigens beween North and Sourth Han Chinese people. Compared with the date of other minority nationalities, this result approaches that of North-Chinese minority pationalities such as Korean, Mongolian, etc.