AN EXPERIMENTAL STUDY ON UVEOSCLERAL OUTFLOW WITH FITC-BSA AS A TRACER IN RABBIT EYE |
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Authors: | Wang Jianming Sun Naixue Yu Yinggui Wang Kangmin Wang Aiqing |
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Abstract: | It is to discuss the method for studying uveoscleral
pathway and the influence of uveoscleral outflow on aqueous humor drainage. Seventeen
rabbits were randomly divided into the flow group that included 5 rabbits and the morphological
group that included 12. Fluoresceinisothiocyanate bovine serum albumin (FITCBSA) was
perfused into anterior chambers of flow group rabbit eyes as the tracer for measuring
uveoscleral outflow. This tracer was infused into anterior chambers of morphological group
rabbit eyes for observing fluorescent intensity of all tissue of the uveoscleral pathway with
fluorescence microscopy. Fluorescence was seen in all sites of uveoscleral pathway. The
fluorescent intensity of ciliary body and suprachoroidal space was significantly stronger than
that of anterior sclera (P<005). The intensity of choroid and posterior sclera was significantly
weaker than that of other tissues (P<005). The average value of uveoscleral outflow was
(0180031) l/min. This study demonstrates that uveoscleral pathway plays an important role in
aqueous humor drainage. Anterior sclera is the main site where aqueous humor flows out.
FITCBSA is an effective tracer for studying uveoscleral pathway from both morphological and
functional aspects. |
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Keywords: | uveoscleral pathway aqueous humor drainage FITCBSA |
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