| Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10 |
| |
| 引用本文： | QingYinZheng BelindaSHarris PatriciaFWard-Bailey HepingYu RoderickTBronson MurielTDavisson KennethRJohnson. Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10[J]. 西安交通大学学报(英文版), 2004, 16(1): 91-91 |
| |
| 作者姓名： | QingYinZheng BelindaSHarris PatriciaFWard-Bailey HepingYu RoderickTBronson MurielTDavisson KennethRJohnson |
| |
| 作者单位： | TheJacksonLaboratory,BarHarbor,Maine04609,USA |
| |
| 摘 要： | Objective To map a mouse deafness gene.identify the underlying mutation and develop a mouse model for human deafncss.Methods Genetic lindage cross and genome scan wer used to map a novel mutation named hypoplasia of the membranous labyrinth (hml),which causes hearing loss in mutant mice.Results ① hml was mapped on mouse Chr 10 (～43 cM from the centromere) suggests that the homologous human gene is on 12q22--q24, which was defined on the basis of known mouse-human homologies (OMIM,2004). ② This study has generated 25 polymorphic microsateUite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500 kb area.
|
| 关 键 词： | 老鼠 耳聋基因 基因突变 遗传因子 |
Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10 |
| |
| Qing Yin Zheng,Belinda S Harris,Patricia F Ward-Bailey,Heping Yu,Roderick T Bronson,Muriel T Davisson,Kenneth R Johnson. Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10[J]. Academic Journal of Xi’an Jiaotong University, 2004, 16(1): 91-91 |
| |
| Authors: | Qing Yin Zheng Belinda S Harris Patricia F Ward-Bailey Heping Yu Roderick T Bronson Muriel T Davisson Kenneth R Johnson |
| |
| Abstract: | Objective To map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness. Methods Genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. Results ① hml was mapped on mouse Chr 10 (～43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). ② This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500 kb area. |
| |
| Keywords: | mouse deafness mutation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
