| PCR早期诊断结核性胸膜炎的临床价值 |
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| 引用本文： | 杨栓盈,杨德昌,李秀霞,王香玲.PCR早期诊断结核性胸膜炎的临床价值[J].西安交通大学学报(英文版),1997(2). |
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| 作者姓名： | 杨栓盈 杨德昌 李秀霞 王香玲 |
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| 作者单位： | 西安第二临床医学院内科学教研室，西安第二临床医学院内科学教研室，西安第二临床医学院内科学教研室，西安第二临床医学院内科学教研室 西安，710004，西安，710004，西安，710004，西安，710004 |
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| 摘 要： | 比较了PCR、涂片法、OT试验及胸膜活检4种方法诊断结核性胸膜炎的临床价值。结果显示：PCR法灵敏度为48％,显著高于其它诸法(P＜0．05或0．01),其特异度为91．6％,与其它诸法接近(P均＞0．05)。PCR法具有快速、灵敏、简便及不依赖结核菌培养等优点,应作为胸腔积液患者的常规检查项目。但其假阴性率、假阳性率分别达52％和8．4％,致其可信性受限。本文对产生假阴性和假阳性的原因进行了分析,并提出了减少假阴性和假阳性的方法。
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| 关 键 词： | 聚合酶链反应 诊断 结核 胸腔积液 |
CLINICAL VALUE OF PCR IN EARLY DIAGNOSIS OF TUBERCULOUS PLEURISY |
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| Yang Shuanying, Yang Dechang, Li Xiuxia et al.CLINICAL VALUE OF PCR IN EARLY DIAGNOSIS OF TUBERCULOUS PLEURISY[J].Academic Journal of Xi’an Jiaotong University,1997(2). |
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| Authors: | Yang Shuanying Yang Dechang Li Xiuxia |
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| Abstract: | The aim of this work is to investi-gate the clinical value of PCR, smear, OT test and biopsy of pleura in early diagnosis of tuberculous pleurisy. The results showed that sensitivity of PCR was 48%, which was significantly higher than other methods' (P < 0. 05 ). In addition to the above,PCR had many advantages such as quickness, con-venience and non-depending on culture of the tuber-cle bacillus. So it should be a routine laboratory test for patients with hydrothorax but there existed false negative rate of 52 % and false posltive rate of 8. 4%by using this method, which seriously reduced its reliability. The authors also analysed the reasons of false negativeness and false positiveness, and put forward some measures to attenuate them. |
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| Keywords: | polymerase chain reaction diagnosis tuberculosis pleural effusion |
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