THE RELATION BETWEEN CHRONIC HBsAg CARRIER STATE AND GENETIC FACTOR

ＴＨＥＲＥＬＡＴＩＯＮＢＥＴＷＥＥＮＣＨＲＯＮＩＣＨＢｓＡｇＣＡＲＲＩＥＲＳＴＡＴＥＡＮＤＧＥＮＥＴＩＣＦＡＣＴＯＲＭｅｎＢｏｙｕａｎ（门伯媛）；ＷａｎｇＷｅｎｊｕａｎ（王文娟）；ＸｕＨｕｉｗｅｎ（徐慧文）；ＬｉｕＰｅｎｇｈｂ（刘蓬勃）（Ｄｅｐａｒｔ...

THE RELATION BETWEEN CHRONIC HBsAg CARRIER STATE AND GENETIC FACTOR

HBsAg positive families including 375 indiduals were investigated in genetic epidemiology.The results showed the HBsAg carrier rate of the blood relatives was significantly higherthan that of the non-blood relatives(P<0.01).The HBsAg carrier rate decreased with the degreeof relatives,that is,the HBsAg carrier rate of the lst degree relatives was higher than that of the 2nddegree relatives and the HBsAg carrier rate or the 2nd degree relatives wus higher than that of the3rd degree relatives(P<0.01).The HBsAg carrier rate of the individuals living together with theprobands was higher than that of those living apart (P<0.01).But the other two marker of HBVinfectivity,anti-HBs and anti-HBc didn't show significant difference mentioned above.The resultsanalysed by means of Logistic Regression model showed blood relationship played an important rolein HBsAg carrier state.In addition,the history of common environment was associated with HBsAgcarrier state.The average of heritability in the 1st,2nd,3rd degree relatives was 88.80%.Analysis.of genetic model showed HBsAg carrier saute corresponded to the ckaracteristic of multifactorial genetic disease,excluding the possibility of single gene genetic disease.