| 大鼠游离血硒及心肌硒动力学研究 |
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| 引用本文： | 李泂,张树声,王德全.大鼠游离血硒及心肌硒动力学研究[J].西安交通大学学报(医学版),1990(4). |
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| 作者姓名： | 李泂 张树声 王德全 |
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| 作者单位： | 西安医科大学核医学研究室
(李泂，张树声)，西安医科大学核医学研究室(王德全) |
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| 摘 要： | 本实验以放射性~(75)Se-亚硒酸钠示踪方法和离体大鼠心肌组织切片温育及灌流方法,观察了大鼠游离血硒与血清硒、服硒剂量的数量关系,比较了心肌组织对血清硒和游离血硒的摄取过程,计算了给硒后不同时刻的心肌硒代谢速率及掺入量,以及硒浓度对掺入过程的影响。结果表明:游离血硒与心肌硒代谢关系十分密切;血清硒的游离结合比值有可能成为一种比较稳定的硒代谢指标;游离血硒可能是研究硒代谢的重要中间产物。
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| 关 键 词： | 克山病 硒 药物动力学 放射性示踪 同位素 |
A STUDY ON THE FREE SELENICS IN THE SERUM OF RATS AND THEIR KINETICS IN THE MYOCARDIUM |
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| Li Jiong,Zhang Shusheng,Wang Dequan,et al.A STUDY ON THE FREE SELENICS IN THE SERUM OF RATS AND THEIR KINETICS IN THE MYOCARDIUM[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(4). |
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| Authors: | Li Jiong Zhang Shusheng Wang Dequan |
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| Institution: | Department of Nuclear Medicine |
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| Abstract: | By tracing of ~(75)Se-Na_2SeO_3 incubating and irrigating of the isolated myocardial slices of rats, the numeric relationship between the free selenics in the serum and the serum sdenics, the sodium sdenite doses injected were observed; the absorption of the frce selenics and the serum selenics was compared; the setenics metabolic rate and quantities of the myocardial tissue in different duration after injecting of selcnite, the effect of selenics concentration to the participating were calculated, It is suggested that there is a very close relationship between the free selenics and the selenium metabolism in the myocardium; the ratio betwen the values of the free selenics and the serum selenics may become a stable indicator of the selenium metabolism; the free selenics in the serum may be where the important mediates of selenium metabolism are. |
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| Keywords: | Keshan disease selenium radiotracing pharmacokinctics isotope |
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