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| 益肾胶囊对慢性肾小球肾炎患者sEPCR及CD62P的影响 | |
| 引用本文： | 吴喜利,张王刚,石兴民,安鹏,孙万森,王竹,乔成林.益肾胶囊对慢性肾小球肾炎患者sEPCR及CD62P的影响[J].西安交通大学学报(医学版),2010,31(2). |
| 作者姓名： | 吴喜利 张王刚 石兴民 安鹏 孙万森 王竹 乔成林 |
| 作者单位： | 1. 西安交通大学医学院第二附属医院中西医结合科,陕西省中医重点专科-肾病科,陕西西安,710004 2. 西安交通大学医学院第二附属医院血液科,陕西西安,710004 3. 西安交通大学医学院,陕西西安,710061 |
| 基金项目： | 陕西省中医管理局资助项目(No.2003158)Supported by the Administration of Traditional Chinese Medicine of Shaanxi Province |
| 摘 要： | 目的 观察益肾胶囊对慢性肾小球肾炎(慢性肾炎,chronic glomerulonephritis, CGN)患者血浆可溶性内皮细胞蛋白C受体(soluble endothelium protein C receptor, sEPCR)、P-选择素(P-selectin, CD62P)及血清免疫球蛋白(Ig)、补体3水平的影响.方法 分别采用酶联免疫双抗体夹心法、流式细胞仪及免疫比浊法检测了40例健康查体者和78例患者治疗前后血浆sEPCR、CD62P及血清免疫球蛋白(Ig)、补体3水平的改变.结果 治疗前慢性肾炎患者血浆sEPCR、CD62P及血清IgA水平均明显升高(P<0.01),血清IgG、IgM及补体C3水平明显降低(P<0.01),经过3个月的治疗,治疗组患者血浆sEPCR、CD62P及血清IgA水平明显下降(P<0.05或P<0.01),IgG、IgM及补体C3明显升高(P<0.05或P<0.01).结论 益肾胶囊治疗CGN患者的作用机制之一可能与降低血浆sEPCR、CD62P水平及调节血清IgA、IgG、IgM和补体C3水平有关. |
| 关 键 词： | 益肾胶囊 慢性肾小球肾炎 可溶性内皮细胞蛋白C受体 P-选择素 |
Effects of Yishen Capsule on sEPCR and CD62P in patients with chronic glomerulonephritis |
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| WU Xi-li,ZHANG Wang-gang,SHI Xing-min,AN Peng,SUN Wan-sen,WANG Zhu,QIAO Cheng-lin.Effects of Yishen Capsule on sEPCR and CD62P in patients with chronic glomerulonephritis[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2010,31(2). | |
| Authors: | WU Xi-li ZHANG Wang-gang SHI Xing-min AN Peng SUN Wan-sen WANG Zhu QIAO Cheng-lin |
| Institution: | WU Xi-li1,ZHANG Wang-gang2,SHI Xing-min3,AN Peng1,SUN Wan-sen1,WANG Zhu1,QIAO Cheng-lin1(1.Department of Integrated Chinese Traditional , Western Medicine,the Second Affiliated Hospital,Medical School of Xi\'an Jiaotong University/Shaanxi Province Key TCM Department of Nephrology,Xi\'an 710004,2.Department of Hematology,Medical School ofXi\'an Jiaotong University,3.Medical School ofXi\'an Jiaotong University,Xi\'an 710061,China) |
| Abstract: | Objective To explore the effects of Yishen Capsule on the soluble endothelium protein C receptor(sEPCR) and P-selectin(CD62P) as well as the serum levels of immunoglobulin(Ig) and complement 3(C3) in patients with chronic glomerulonephritis(CGN).Methods The changes of sEPCR and CD62P levels in plasma as well as Ig and C3 levels in serum were assessed in 40 normal subjects and 78 patients before and after treatment by double-antibody enzyme-linked immunosorbent assay,flow cytometry and immunoturbidimetry,res... |
| Keywords: | Yishen Capsule chronic glomerulonephritis soluble endothelium protein C receptor (sEPCR) P-selectin (CD62P) |
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