亚胺环己酮与甲基强的松龙治疗大鼠脊髓损伤的初步研究

目的　为脊髓损伤的临床药物治疗提供新的理论依据。方法　将 48只大鼠用 Allen法制成脊髓损伤模型 ,分别予以亚胺环己酮、甲基强的松龙、二药联合应用及不予治疗。观察动物不同时期神经功能评分 ,斜板试验及体表诱发电位。结果　从伤后 3周起 ,治疗组各种指标与对照组有显著差异 ,而各治疗组间无差异。结论　早期应用亚胺环己酮与甲基强的松龙治疗脊髓损伤均有效 ,但二者合用不能提高疗效

Cycloheximide and methlprednisolone in the treatment of early spinal cord injury in rats

Objective To observe the effects of single and conjunctive pharmaceutical therapy of cycloheximide and methlprednisolone in treatment of spinal cord injury.Methods 48 rats model of spinal cord injury made by Allen method and randomly divided into 4 groups in which they received cycloheximide, methlprednisolone, conbined two or no treatment respectively ,and raised for 6 weeks.The Tarlov scale and inclined plane test and SEP were observed at several time points after injury.Results In the 3 week significant differences were shown between treated and control group and no significant differences among treated groups in Tarlov scale and inclined plane test.Conclusion Cycloheximide and methlprednisolone were effective in treatment of early spinal cord injury and both showed neuroprotective effects,but there was no significant differences between conjunctive and single therapy.