| 基于网络构建方法探究遗传疾病的发病机制 |
| |
| 引用本文： | 张世华,张旭,孙峰.基于网络构建方法探究遗传疾病的发病机制[J].交通科技与经济,2011,13(5):113-114,118. |
| |
| 作者姓名： | 张世华 张旭 孙峰 |
| |
| 作者单位： | 黑龙江工程学院电子工程系,黑龙江哈尔滨,150050 |
| |
| 基金项目： | 黑龙江省教育厅科学技术研究项目(11541298) |
| |
| 摘 要： | 基于网络构建的方法构建疾病表型相关网络,并对网络作拓扑学结构和功能分析。结果提示表型相关的疾病在分子层面上有一定的相似性,这为相关疾病药物靶标的选择和个性化治疗提供一定的临床指导意义。
|
| 关 键 词： | 网络 分子机制 表型 |
Probing Morbid Mechanism of Inherited Disease Based on Network Construction Approach |
| |
| ZHANG Shi-hua,ZHANG Xu,SUN Feng.Probing Morbid Mechanism of Inherited Disease Based on Network Construction Approach[J].Technology & Economy in Areas of Communications,2011,13(5):113-114,118. |
| |
| Authors: | ZHANG Shi-hua ZHANG Xu SUN Feng |
| |
| Institution: | ZHANG Shi-hua,ZHANG Xu,SUN Feng(Department of Electronic Engineering,Heilongjiang Institute of Technology,Harbin 150050,China) |
| |
| Abstract: | Disease phenotype network was constructed based on our devised network construction approach,and then analyzed in aspects of topology and function.Our results suggested that relevant diseases have some relevance in molecular mechanism,which providing clinic guidance for drug target selection of related diseases. |
| |
| Keywords: | network molecular mechanism phenotype |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
