| 肾移植患者应用更昔洛韦后环孢菌素A的药动学及临床生化指标的研究 |
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| 引用本文： | 闫正华,王茂义,黄猛,董卫华,吴雪峰. 肾移植患者应用更昔洛韦后环孢菌素A的药动学及临床生化指标的研究[J]. 西安交通大学学报(医学版), 1999, 0(2) |
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| 作者姓名： | 闫正华 王茂义 黄猛 董卫华 吴雪峰 |
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| 作者单位： | Department of Pharmacy,First Affiliated Hospital |
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| 基金项目： | 陕西省科学技术研究发展计划项目 |
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| 摘 要： | 对１０例肾移植患者应用与未用更昔洛韦后环孢菌素Ａ的药动学参数及临床生化指标进行研究。采用荧光偏振免疫法测定血药浓度,３Ｐ８７程序拟合药动学参数。结果显示：应用更昔洛韦后,环孢菌素Ａ药动学参数Ｋｅ、ｔ１／２（Ｋａ）分别由未用组的（０．１６±０．０４）ｈ－１和（１．３９±０．７６）ｈ降至（０．０９±０．０５）ｈ－１和（０．５０±０．３２）ｈ（Ｐ＜０．０５）,Ｔｍａｘ由（３．６７±０．７７）ｈ减至（２．００±０．７８）ｈ（Ｐ＜０．０１）,ｔ１／２（Ｋｅ）由（４．０８±１．８５）ｈ增至（１０．５１±６．４２）ｈ（Ｐ＜０．０５）,峰浓度Ｃｍａｘ平均升高２７％。肾移植后应用更昔洛韦组肾功指标下降,肝功指标上升,其中血清肌酐、总胆红质与未用组相比有统计学意义。表明更昔洛韦使肾移植患者环孢菌素Ａ的药动学参数及临床生化指标发生改变,提示临床调整用药方案。
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| 关 键 词： | 药动学参数 临床生化指标 环孢菌素A 更昔洛韦 肾移植 |
THE EFFECT OF GANCICLOVIR ON PHARMACOKINETICSOF CYCLOSPORIN A AND CLINICAL BIOCHEMISTRYINDICATIONS IN KIDNEY TRANSPLANT PATIENTS |
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| Yan Zhenghua,Wang Maoyi,Huang Meng et al. THE EFFECT OF GANCICLOVIR ON PHARMACOKINETICSOF CYCLOSPORIN A AND CLINICAL BIOCHEMISTRYINDICATIONS IN KIDNEY TRANSPLANT PATIENTS[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1999, 0(2) |
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| Authors: | Yan Zhenghua Wang Maoyi Huang Meng et al |
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| Abstract: | To observe the effect of ganciclovir on pharmacokinetics parameters of cyclosporin A in kidney transplant patients.Pharmacokinetics parameters of cyclosporin A and clinical biochemistry indications were studied in 10 patients after single administration of cyclosporin A and after additional administration of ganciclovir respectively.Fluorescence polarization immunoassay method was applied for the determination of cyclosporin A in blood.And pharmacokinetics parameters were fitted with 3P87 program.After additional administration of ganciclovir, the Ke and T1/2(Ka)of cyclosporin A decreased from (0.160.04)h-1 and (1.390.76)h to (0.090.05)h-1and (0.500.32)h respectively (P<0.05).And the Tmaxwas reduced from (3670.77)h to (200078)h(P<0.01),The T1/2(Ke) increased from (4081.85)h to (10.516.42)h(P<0.05),The Cmax ascended by 27% .Levels of renal function were decreased while those of hepar function were increased. |
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| Keywords: | pharmacokinetics parameters clinical biochemistry indications cyclosporin A ganciclovir kidney transplantation |
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