|
|||||
|
|
| 上皮钙粘附分子在膀胱移行细胞癌中的表达及意义 | |
| 引用本文： | 庞新路,石涛,王子明,种铁,苏宝山.上皮钙粘附分子在膀胱移行细胞癌中的表达及意义[J].西安交通大学学报(医学版),2003,24(5):484-486. |
| 作者姓名： | 庞新路 石涛 王子明 种铁 苏宝山 |
| 作者单位： | 1. 西安交通大学第一医院肾移植科,陕西西安,710061 2. 西安交通大学第二医院泌尿外科,陕西西安,710061 3. 西安交通大学第二医院病理科,陕西西安,710004 |
| 摘 要： | 目的 探讨上皮钙粘附分子 (epithelialcadherin ,E cad)在膀胱移行细胞癌中的表达及临床意义。方法 应用免疫组化SP法检测 5 7例膀胱移行细胞癌组织中E cad的表达。结果 ①E cad在膀胱癌中异常表达与膀胱癌的病理分级、临床分期及预后呈正相关 (P <0 .0 5 ,P <0 .0 1) ;②E cad在膀胱癌中的异常表达与膀胱癌的复发呈负相关 (P <0 .0 1)。结论 E cad表达可作为判断膀胱癌恶性程度及预后和复发的生物学指标 |
| 关 键 词： | 膀胱移行细胞癌 上皮钙粘附分子 免疫组织化学 |
| 文章编号： | 1671-8259(2003)05-0484-03 |
| 修稿时间： | 2002年11月1日 |
The expression of E-cadherin protein in transitional cell cancer of bladder and its significance |
|
| Pang Xinlu,Shi Tao,Wang Ziming,Chong Tie,Su Baoshan.The expression of E-cadherin protein in transitional cell cancer of bladder and its significance[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2003,24(5):484-486. | |
| Authors: | Pang Xinlu Shi Tao Wang Ziming Chong Tie Su Baoshan |
| Abstract: | Objective To study the expression of E-cadherin protein in transitional cell cancer of bladder and its significance.Methods E-cadherin was detected by immunohistochemical SP method in 57 cases of bladder cancer and 7 cases of normal bladder tissues.Results Abnormal expression frequency of E-cadherin in G 3 group, invasive group were higher than that in G 1/G 2 group and superficial group (P<0.05). The frequency in recurrence group was lower than that in non-recurrence group (P<0.01). The 3-year overall survival rate of patients with normal E-cadherin expression was significantly higher than for patients with aberrant expression (P< 0.01).Conclusion These results suggest that E-cadherin expression can serve as a recurrence and prognostic indicator for bladder cancer. |
| Keywords: | E-cadherin bladder transitional cell carcinoma immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |