| 鼠~(75)Se—亚硒酸钠的药物动力学研究 |
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| 引用本文： | 姚正生,廖达江,张树声,钱传荣,王德全,徐光禄,王世臣.鼠~(75)Se—亚硒酸钠的药物动力学研究[J].西安交通大学学报(医学版),1991(4). |
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| 作者姓名： | 姚正生 廖达江 张树声 钱传荣 王德全 徐光禄 王世臣 |
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| 作者单位： | 西安医科大学核医学研究室
(姚正生，廖达江，张树声，钱传荣，王德全)，西安医科大学克山病研究室
(徐光禄)，西安医科大学克山病研究室(王世臣) |
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| 基金项目： | 国家七.五攻关科研项目 |
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| 摘 要： | 本文给大、小白鼠注射~(75)Se-亚硒酸钠,研究了硒的药物动力学变化及各种因素的影响。结果表明:硒在大、小鼠体内的药物动力学符合二室开放模型,不同给药途径无明显影响;硒经胃吸收良好,体内分布以肝肾最高,其次为血液、肺、脾、胃肠、心脏等。机体摄入多量以至中毒量硒以后,各组织通过延缓吸收、增加排泄来缓解硒浓度,过量未排泄的硒则进入血细胞内储存。给低硒动物硒制剂后,各组织通过加快吸收,延缓排泄而有效地保留硒。本实验阐明了硒的代谢动力学规律,为硒的临床应用提供了实验依据。
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| 关 键 词： | ~(75)Se-亚硒酸钠 药物动力学 低硒 大白鼠 小白鼠 |
THE STUDY ON PHARMACOKINETICS OF ~(75)Se-SELENITE IN RATS AND MICE |
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| Yao Zhengsheng,Liao Dajang,Zhang Shusheng,et al.THE STUDY ON PHARMACOKINETICS OF ~(75)Se-SELENITE IN RATS AND MICE[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1991(4). |
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| Authors: | Yao Zhengsheng Liao Dajang Zhang Shusheng |
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| Institution: | Yao Zhengsheng;Liao Dajang;Zhang Shusheng;et al Department of Nuclear Medicine |
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| Abstract: | The rats and mice were injected with ~(75)Se-seleniteand selenium pharmacokinetics was studied. The resultsshow that the blood ~(75)Se concentration time curve con-forms to a two compartment model and there are nosignificant differences with administration routes. Theselenium absorption through gastrointestine is quiterapid and complete, Liver and kidney contain moreselenium in the distribution and next are blood, lung,herat, spleen and gastroinrestine. After taking in high ortoxic dose of selenium, animals relieve toxicty throughslowering absorption and accellerating excrtion, and theextra selenium enters into blood cells. However, whenin low selenium status, an opposite pattern was ob-served to maintain the selenium level. The experimentdemonstrated the selenium pharmacokinetics and sup-plied basis for its clinical applications. |
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| Keywords: | selenium radioisotope pharmacokinetics selenium deficiency rats mice |
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