大鼠糖尿病痛过敏模型的建立

用腹腔注射链尿佐菌素（ＳＴＺ）建立糖尿病大鼠模型，然后观察其体重、血糖和运动神经传导速度（ＭＮＣＶ）的变化，并以伤害性爪回缩反射和甩尾反射为痛指标测量痛阈。结果表明：腹腔注射ＳＴＺ后，大鼠血糖升高（血糖＞１１．１ｍｍｏｌ／Ｌ），体重增长迟缓，ＭＮＣＶ减慢；实验至第１周时，甩尾反射潜伏期（ＴＦＬ）显著缩短，第２周时，伤害性爪回缩阈值（ＮＰＷＴ）明显降低。上述结果提示，大鼠已产生糖尿病，并处于痛过敏状态。

THE SETTING UP OF A RAT MODEL OF DIABETIC HYPERALGESIA

After rats were intraperioneally injected with streptozotocin(STZ),their body weight, blood glucose, motor nerve conduction velocity(MNCV), tail flick latency (TFL)and nociceptive paw-withdrawal threshold(NPWT)were observed systematically.The results showed that in the group of rats blood glucose increased(blood glucose>11.1mmol/L), body weigh slowly grew and MNCV reduced.At the first week of the exoperiment,TFL significantly reduced,at the second week,NPWT reduced,too.The above results suggest that the rats have suffered from diabetes,and they have developed hyperalgesia.