| EFFECT OF SIBELIUM ON HYPOXIC CULTURED NEURONS FROM NEWBORN RATS CEREBRAL CONTEX IN VITRO |
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| 引用本文： | 刘小红,陈征起,和光祖.EFFECT OF SIBELIUM ON HYPOXIC CULTURED NEURONS FROM NEWBORN RATS CEREBRAL CONTEX IN VITRO[J].西安交通大学学报(英文版),1996(1). |
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| 作者姓名： | 刘小红 陈征起 和光祖 |
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| 作者单位： | Department Of Pediatrics，First Affiliated Hospital，Xi'an Medical University，Xi'an，710061 |
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| 摘 要： | ＥＦＦＥＣＴＯＦＳＩＢＥＬＩＵＭＯＮＨＹＰＯＸＩＣＣＵＬＴＵＲＥＤＮＥＵＲＯＮＳＦＲＯＭＮＥＷＢＯＲＮＲＡＴＳＣＥＲＥＢＲＡＬＣＯＮＴＥＸＩＮＶＩＴＲＯ（刘小红）（陈征起）（和光祖）ＬｉｕＸｉａｏｈｏｎｇ；ＣｈｅｎＺｈｅｎｇｑｉ；ＨｅＧｕａｎｇｚｕ；...
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| 关 键 词： | Sibeiium primary cultures or neurons hypoxia membrane-fluidity LDH ￣3H-TDR ￣3H-UR |
EFFECT OF SIBELIUM ON HYPOXIC CULTURED NEURONS FROM NEWBORN RATS CEREBRAL CONTEX IN VITRO |
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| Liu Xiaohong,Chen Zhengqi,He Guangzu,.EFFECT OF SIBELIUM ON HYPOXIC CULTURED NEURONS FROM NEWBORN RATS CEREBRAL CONTEX IN VITRO[J].Academic Journal of Xi’an Jiaotong University,1996(1). |
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| Authors: | Liu Xiaohong Chen Zhengqi He Guangzu |
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| Abstract: | Primary cultures of rat cerebral corticai neurons were prepared from conices or 2 days Sprague-Dawlley rats.We made an attempt to imitate the hypoxic neurons injury for testing neuroprotective erfect or Sibelium. It was found that Sibelium could significantly decrease the amounts of LDH leaking from intracellular fluid and increase the neuron-membrane fluidity of hypoxic neurons.Hypoxic group had significantly higher incorporation of 3H-TDR and 3H-UR than control group,while Sibelium could decrease the incorporation of 3H-TDR and 3H-UR. In addition,Sibelium could decrease the incorporation of 3H-TDR and 3H-UR in normal cultured neurons.The results showed that Sibelium could protect the neuronmembranes against alteration caused by hypoxia and regulate the synthesis of DNA and RNA. |
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