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APPLICATION OF HMB-45 MONOCLONAL ANTIBODY AND S100 PROTEIN IN THE IMMUNOHISTOCHEMICAL DIAGNOSIS OF MELANOMA
引用本文:刘丹亚,苏宝山,徐汉卿. APPLICATION OF HMB-45 MONOCLONAL ANTIBODY AND S100 PROTEIN IN THE IMMUNOHISTOCHEMICAL DIAGNOSIS OF MELANOMA[J]. 西安交通大学学报(英文版), 1995, 0(1)
作者姓名:刘丹亚  苏宝山  徐汉卿
作者单位:Liu Danya;Su Baoshan;Xu Hanqing(Departmeat of Drmatology,Second Affiliated Hospital,Xi'an Medical University,Xi'an710004).(Dept. of Pathology,Second Affiliated Hospital,Xi'an Medical University)
摘    要:APPLICATIONOFHMB-45MONOCLONALANTIBODYANDS100PROTEININTHEIMMUNOHISTOCHEMICALDIAGNOSISOFMELANOMALiuDanya(刘丹亚);SuBaoshan(苏宝山);Xu...


APPLICATION OF HMB-45 MONOCLONAL ANTIBODY AND S100 PROTEIN IN THE IMMUNOHISTOCHEMICAL DIAGNOSIS OF MELANOMA
Liu Danya,Su Baoshan,Xu Hanqing. APPLICATION OF HMB-45 MONOCLONAL ANTIBODY AND S100 PROTEIN IN THE IMMUNOHISTOCHEMICAL DIAGNOSIS OF MELANOMA[J]. Academic Journal of Xi’an Jiaotong University, 1995, 0(1)
Authors:Liu Danya  Su Baoshan  Xu Hanqing
Abstract:We tested a variety of fixed embedded sections of malignant tumors with HMB-45 MoAband S-100 polyclonal antibody.The results showed that RMB-45 was a highly sensitive and specificantibody for recongnizing melanoma on fixed paraffin-embedded tissue sections, it reacted with 96.6percent of melanomas tested(all primary and 6 of 7 metastatic lesions)Both pigmented and nonpigmeated melanomas were recongnized.Malignant tumors of epithelial,lymphoid and mesenchymal origin were all negative.Although antibody to S-100 protien quite sensitive,it was not melanome-specific and it reached with all melanomas including the one metastatic melanoma that did not react withHMB-45,it we also positive in one of five lymphomas and one of three sarcomas.AdditionallyHMB-45 reacted with junctional nevi and componentes of compound neai and not with intradermalnevi and the dermal components of compound nevi.
Keywords:HMB-45  S-100 protein  melignant melanoma  melanocytic nevi  immunohis tochemical  tumors
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