| Effects of rhubarb extracts on hyperexcitability of hippocampal CA1 neurons after fluid percussion injury |
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| 引用本文： | 张爱华 顾建文 郑崇勋 裴晓梅. Effects of rhubarb extracts on hyperexcitability of hippocampal CA1 neurons after fluid percussion injury[J]. 西安交通大学学报(英文版), 2007, 19(1): 73-76,100 |
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| 作者姓名： | 张爱华 顾建文 郑崇勋 裴晓梅 |
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| 作者单位： | Key Laboratory of Biomedical Information Engineering of Education Ministry, Xi＇an Jiaotong University, Xi＇an 710049, China |
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| 摘 要： | Objective To investigate the effects of rhubarb extracts, i.e. rhein and emodin, on the neuronal hyperexcitability and synaptic transmission, and to ,further reveal the mechanism of the secondary brain damage. Methods The fluid percussion injury （FPI） rat model and extracellular recording method were used. The evoked field potentials by stimulating Schaffer collaterals were collected from the ipsilateral （impact side） and the contralateral hippocampal CA1 areas of rat in vitro . And the field potentials, including the field excitatory postsynaptic potential and the population spike, were analyzed. Results After the impact was performed on the rat parietal cortex, the evoked field potentials in the ipsilateral hippocampus CA1 area were enhanced obviously. Rhubarb extracts reduced the slope of the field excitatory postsynaptic potential and the number of the population spike significantly while rhein and emodin increased the latency of the population spike obviously. Conclusion Rhubarb extracts, i.e. rhein and emodin, can depress the neuronal hyperexcitability, which suggests that rhein and emodin play an important role in protecting the central nervous system from neuronal damage after traumatic brain injury. FPI produces hyperexcitability of hippocampal CA1 neurons, probably by enhancing excitatory synaptic transmission.
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| 关 键 词： | 流体冲击伤 海马CA1神经元 兴奋过度 大黄提取物 疗效 脑损伤 |
| 文章编号： | 1671-8267（2007）01-0073-04 |
Effects of rhubarb extracts on hyperexcitability of hippocampal CA1 neurons after fluid percussion injury |
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| Zhang Aihua,Gu Jianwen,Zheng Chongxun,Pei Xiaomei. Effects of rhubarb extracts on hyperexcitability of hippocampal CA1 neurons after fluid percussion injury[J]. Academic Journal of Xi’an Jiaotong University, 2007, 19(1): 73-76,100 |
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| Authors: | Zhang Aihua Gu Jianwen Zheng Chongxun Pei Xiaomei |
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| Abstract: | Objective To investigate the effects of rhubarb extracts,i.e.rhein and emodin,on the neuronal hyperexcitability and synaptic transmission,and to further reveal the mechanism of the secondary brain damage.Methods The fluid percussion injury(FPI) rat model and extracellular recording method were used.The evoked field potentials by stimulating Schaffer collaterals were collected from the ipsilateral(impact side) and the contralateral hippocampal CA1 areas of rat in vitro.And the field potentials,including the field excitatory postsynaptic potential and the population spike,were analyzed.Results After the impact was performed on the rat parietal cortex,the evoked field potentials in the ipsilateral hippocampus CA1 area were enhanced obviously.Rhubarb extracts reduced the slope of the field excitatory postsynaptic potential and the number of the population spike significantly while rhein and emodin increased the latency of the population spike obviously.Conclusion Rhubarb extracts,i.e. rhein and emodin,can depress the neuronal hyperexcitability,which suggests that rhein and emodin play an important role in protecting the central nervous system from neuronal damage after traumatic brain injury.FPI produces hyperexcitability of hippocampal CA1 neurons,probably by enhancing excitatory synaptic transmission. |
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| Keywords: | rhubarb brain injury hippocampus field potential excitability |
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