| 碘化二甲基木防己碱对大鼠血脂及家兔血液流变学的影响 |
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| 引用本文： | 袁秉祥,吴英,蒙秋锁,王瑜.碘化二甲基木防己碱对大鼠血脂及家兔血液流变学的影响[J].西安交通大学学报(医学版),1990(4). |
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| 作者姓名： | 袁秉祥 吴英 蒙秋锁 王瑜 |
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| 作者单位： | 西安医科大学药学系药理学教研室
(袁秉祥，吴英)，西安医科大学第一附属医院检验科
(蒙秋锁)，西安医科大学第一附属医院检验科(王瑜) |
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| 摘 要： | 本文研究DTI对大鼠血脂、血脂蛋白胆固醇及家兔血液流变学指标的影响。DTI 0.5mg/kg腹腔注射可升高正常大鼠的TG,降低正常大鼠和高脂饲养大鼠的HDL-c和HDL—c/LDL—c;在10μg/kg时静脉注射能促进家兔血栓形成,在5μg/kg和10μg/kg时增加高切变率下血浆粘度。说明DTI对大鼠血脂调理和家兔血液流变学指标可能有不利影响。
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| 关 键 词： | 碘化二甲基木防己碱 血脂 |
EFFECTS OF DIMETHYL TRILOBINE IODIDE ON THE BLOOD LIPIDS OF RATS AND HEMORRHEOLOGY OF RABBITS |
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| Yuan Bingxiang,Wu Ying,Meng Qiusuo,et al.EFFECTS OF DIMETHYL TRILOBINE IODIDE ON THE BLOOD LIPIDS OF RATS AND HEMORRHEOLOGY OF RABBITS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(4). |
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| Authors: | Yuan Bingxiang Wu Ying Meng Qiusuo |
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| Abstract: | The effects of Dimethyl trilobine Iodide (DTI) on the blood lipids and lipoprotein choieslerol of rats and hemorrheology of rabbits were studied An peritoneal injection of DTI at the dosage of 0.5mg/kg could increase the serum TG of normal rais and reduce the HDL-c and HDL-c/LDL-c of rats fed with normal and fat-rich diets. An intravenous injection of DTI at the dosage of 10μg/kg accelerated formation of thrombus in vitro and at 5μg/kg and 10μg/kg elevated plasma mucosity at high sheafing. It was demonstrated that DTI had probably unfavorable effects on mediation of blood lipids of rats and hemorrheology of rabbits. |
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| Keywords: | dimcthyl trilobine iodide lipids hemorrheology |
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