血凝法测定正常人及乙型肝炎患者血清多聚白蛋白受体的临床应用

应用血凝法检测正常人及乙型肝炎患者血清多聚白蛋白受体(polymerized human serum albumin PHSA)。HBeAg阳性的患者受体滴度显著高于抗-HBe阳性的患者(HBeAg阴性),P<0.01。其PHSA几何平均滴度和阳性率分别为:30例正常人2.2±1.42(3.3％);15例慢性活动性肝炎66.9±7.2(80％);15例慢性迁延性肝炎43.73±41.5(73％);17例急性乙型肝炎10.8±9.4(58.5％);16例无症状HBsAg携带者17.5±16.8(25％)。本文结果说明,检测HBsAg颗粒上的PHSA受体对于HBeAg阳性的慢性乙肝患者和HBsAg无症状携带者的区别上是一项有用的临床指标。

CLINICAL APPLICATION OF HEMAGGLUTINATION METHOD TO DETECTION OF RECEPTORS OF POLYMERIZED HUMAN SERUM ALBUMIN IN NORMAL CONTROLS AND HEPATITIS B

A heniagglutination methods was developed to detect the polymerized human serum albumin (PHSA) receptors in hepatitis B. The receptor values on particles from HBeAg-positive patients were significantly higher than those from anti-HBepositivn (HBeAg-negative p<0.01). The geometric mean titer of PHSA and the positive rate were as follows: 2.2+1.42, (3.3%) in 30 normal controls, 43,73±41.5, (73%); in 15 chronic active hepatitis; 66.9±72, (80%); in 15 chronic persistent hepatitis, 10.8±9.4(58.5%) in 17 acute hepatitis and 17.5±16.8, (25%) in 16 asypmtomatic carries. The results suggest that the detection of PHSA receptors on HBeAg particles may serve significantly as a prognostic marker in HBe Ag-positive chronic hepatitis type B and HBeAg-asypmtomatic carries.