Cyclin E及p53的表达与早期胃癌进展及淋巴结转移的关系 |
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引用本文: | 车向明,徐威,帆北修一,爱甲孝. Cyclin E及p53的表达与早期胃癌进展及淋巴结转移的关系[J]. 西安交通大学学报(医学版), 2001, 22(5): 451-453 |
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作者姓名: | 车向明 徐威 帆北修一 爱甲孝 |
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作者单位: | 1. 西安交通大学第一医院普通外科, 2. 日本鹿儿岛大学医学院第外科 |
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基金项目: | 卫生部课题基金资助(941230) |
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摘 要: | 目的 了解CyclinE及 p5 3的表达与早期胃癌进展及淋巴结转移的关系。方法 用免疫组织化学方法检测了 1 0 8例早期胃癌CyclinE及p5 3的表达。结果 CyclinE及p5 3的表达与病人性别及肿瘤组织学类型有关 (P <0 0 5 )。CyclinE异常表达与肿瘤部位、浸润深度及胃壁淋巴管浸润有关 (P <0 0 5 )。CyclinE及p5 3联合异常表达的肿瘤多位于粘膜下 ,伴有淋巴管浸润及淋巴结转移。结论 CyclinE及 p5 3联合异常表达促进早期胃癌的进展及淋巴结转移。
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关 键 词: | CyclinE p53 早期胃癌 淋巴结转移 |
文章编号: | 0258-0659(2001)05-0451-03 |
修稿时间: | 2001-02-22 |
Cyclin E and p53 expression in early gastric cancer:associatio n with tumorprogression and lymph node metastasis |
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Abstract: | Objective To study the relationship among Cyclin E and p53 expression with the progression and lymph node metastasis of early gastric cancer. Methods The expression of Cyclin E and p53 was examined by means of immunohistochemistry in 108 cases with early gastric cancer.Results Both Cyclin E and p53 positive expression related to the gender of patients and the histology of tumors( P <0.05). Abnormal expression of Cyclin E related to tumor location, depth of invasion and lymphatic vessel invasion( P <0.05). Tumors with positive expression of Cyclin E and p53 at the same time were more deeply invaded, accompanied with lymphatic vessel invasion and lymph node metastasis.Conclusion Co-expression of Cyclin E and p53 promote tumor progression and lymph node metastasis in early gastric cancer. |
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Keywords: | Cyclin E p53 early gastric cancer lymph node metastasis |
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