雌、孕激素受体和rasP~(21)蛋白的表达在乳腺癌预后中的意义

用酶联亲合组化法和ABC免疫组化法对93例乳腺癌石蜡标本中雌激素受体(ER)、孕激素受体(PR)和ras P~(21)蛋白进行了检测和对比研究。经果表明:ER、PR阳性率分别为64.52％和60.22％,经随访5年累积无瘤生存率阳性组高于阴性组(P<0.05);P~(21)蛋白的阳性表达率为52.69％,多出现在分化差的Ⅱ、Ⅲ级具有浸润性的乳腺癌组织中,随乳腺癌组织学分级的增加而增强,与ER水平呈负相关,5年累积无瘤生存率阴性组高于阳性组(P<0.05)。认为P~(21)蛋白表达的强弱同ER、PR一样反映了乳腺癌的生物学特性及预后。

THE SIGNIFICANCE OF ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND EXPRESSION OF RAS P~(21) IN THE PROGNOSIS OF BREAST CANCER

With the help of Liu's enzyme liked estrogen (or progesteron) affinity histochemistry method and ABC immunohistochemical technics, the paraffin-specimens of the focuses for 93 cases with breast cancer have been analyzed and studied comparatively for estrogen receptor (ER),progesterone receptor (PR) and ras P21. The results indicated the positive rate of ER and PR was 64.52% and 60.22% respectively, the 5-year cumulative disease free rate of the positive groups was higher than thatof the negative (P < 0. 05) . the positive expression rate of P" was 52. 69% which occurred more frequently in grade I , I with infiltrating tissue of breast cancer, and was negatively co-related to ER. The 5-year cumulative disease free rate of the negative groups was higher than that of the positive groups who take part in a follow-up survey (P< 0. 05) . The experiment suggests that the expression of P" such as ER, PR shows the biological characteristic and the prognosis of breast cancer.