| Abstract: | Objective To investigate the protective effect of ascorbic acld on myocardium from ischemia and reperfusion injury and its electrophysiological mechanism. Methods Using modified Ferrler's arrhythmia induced by ischemia and reperfusion injury in isolated guinea pig right ventricular wall. Results Ascorbic acid at 5, 1o, 5o and 1oopmol/L sllghtly decrease incidence of ischemia arrhythmia (P > o. o5). In contrast, ascorbic acid at 1o, 5o and 1oopmol/L slguificantly reduced the incldence of arrhythmia during early reperfusion(2~12min) (P < o. o1 or P o. o5). However, ascorbic acld abbreviated epicardial conduction time significantly (P < o. o5 or P < o. o1 or P < o. oo1 ). Conclusion The study suggests that ascorbic acld might exert antiarrhythmic effect via alleviating conduction abnormity to avold transmural reentries during ischemia and early reperfusion. |
