CLONING AND EXPRESSION OF A GENE MEDIATING γ-RADIATION-INDUCED APOPTOSIS IN HL-60 CELLS |
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作者姓名: | 李小明 宋天保 童新 孙志贤 |
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作者单位: | Department of Histology and Embryology,Xi'an Medical University,Xi'an 710061Molbiology Lab.,Beijing Institute of Radiation Medicine,Beijing 100850 |
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摘 要: | Apoptosis,orprogrammedcelldeath(PCD),isanintricatelyregulatedprocess">.Geneticstud-iesofapoptosisinCaenorhabditiseleganshavei-dentifiedced-3andced-4asproapoptoticgenesandced-9asanantiapoptoticgene"=-Severalmam-malianhomologuesofced-3,ced-4andced-9havebeenidentified.Recentstudiesindicatethatthefundamentalapoptosismachinery,whichconsistsofdistincteffectors,inhibitorsandinitiators,hasbeenconservedthroughoutevolution.Thekeyapoptosiseffectorsinmammalsareafamilyofcys-teine-containing,aspartate-spe…
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关 键 词: | γ-radiation apoptosis caspasa-3/CPP-32/Yama molecular cloning |
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