| THE EXPRESSION AND CLINICAL SIGNIFICANCE OF P21(WAF1/CIP1) AND CYCLIN D1 PROTEIN IN COLORECTAL CARCINOMA |
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| 作者姓名： | 雷联会 许延发 盛薇 |
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| 作者单位： | Lei Liahui，Xu Yanfa，Sheng WeiDepartment of General Surgery，First Hospital of Xi′an Jiaotong University，Xi′an 710061，China |
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| 摘 要： | Studies on the carcinomas showed thattumori-genesis was critically related to the acceleration ofcell proliferation and disturbance of apoptosis.Ab-normal cell cycle might lead to uncontrolled cellproliferation and promote oncogenesis.P2 1 is awide- spectrum cyclin- dependent kinase inhibitorand negatively control cell cycle progression.Chen1] found thatover- expression of P2 1 can inhibittu-mor growth.Cyclin D1 is a regulatory protein thatcontrol cell cycle transit from G1 into S phase.…
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THE EXPRESSION AND CLINICAL SIGNIFICANCE OF P21 (WAF1/CIP1)AND CYCLIN D1 PROTEIN IN COLORECTAL CARCINOMA |
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| Lei Liahui,Xu Yanfa,ShengWei.THE EXPRESSION AND CLINICAL SIGNIFICANCE OF P21(WAF1/CIP1) AND CYCLIN D1 PROTEIN IN COLORECTAL CARCINOMA[J].Academic Journal of Xi’an Jiaotong University,2000,12(2):160-162,167. |
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| Authors: | Lei Liahui Xu Yanfa ShengWei |
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| Abstract: | Objective To study the effect of P21(WAF1/CIP1) and cyclin D1 and their relationship in colorectal carcinoma.Methods The expression of P21 and cyclin D1 was studied in 40 colorectal carcinoma and 10 normal tissues using S P immunohistochemical technique.Results Decreased expression of P12 and overexpression of cyclin D1 were revealed in colorectal carcinoma.Decreased expression of P21 was related to lymph node metastasis.No correlation was found between cyclin D1 and clinicopathological parameters.Conclusion Decreased expression of P21 and overexpression of cyclin D1 may be involved in colorectal tumorigenesis,and were associated with poor prognosis.No correlation was found between P21 and cyclin D1 in colorectal carcinoma. |
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| Keywords: | colorectal carcinoma P21(WAF1/CIP1) cyclin D1 immunohistochemistry prognosisp |
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