尿酸水平对冠脉病变的预测

目的探讨尿酸水平在冠心病发病中的作用及其与冠脉病变的相关性。方法根据冠状动脉造影结果分为冠心病(CHD)组(164例)和正常对照组(51例),比较两组间尿酸水平的差别及与CHD之间的关系。结果CHD组患者的尿酸水平明显高于正常对照组[(316.67±97.35)μmol/Lvs.(286.16±98.33)μmol/L,P<0.01]。随后进行多元Logistic回归分析,显示在调整了糖尿病、性别和纤维蛋白原(FIB)等因素的作用后,尿酸对回归方程的影响达不到统计学意义。亚组分析显示有高尿酸血症的糖尿病患者冠心病发病风险明显提高。结论高尿酸血症作为独立的冠心病危险因素尚缺乏充分证据,应用尿酸与血糖综合评估冠心病的发生风险可能有一定意义。

The analysis of relationship between uric acid and coronary heart disease

Objective To study the significance of serum uric acid in predicting coronary heart disease(CHD) risk.Methods Uric acid and its relationship with coronary heart disease(CHD) was analyzed in 215 cases who underwent coronary angiogaphy(CHD was present in 164 patients and absent in 51 as normal control group).Results Uric acid was significantly higher in patients with CHD than that in the normal control group [(316.67±97.35)μmol/L vs.(286.16±98.33)μmol/L,P<0.01].Multivariate Logistic regression analysis revealed that uric acid was not a significant variable associated with CHD after other risk factors such as diabetes,gender and fibrinogen were adjusted.The further analysis showed that the risk of patients with diabetes mellitus and high serum uric acid level was much more than that of patients without the two kinds of diseases.Conclusion Uric acid is not a dependent risk in the development of CHD,but uric acid combined with diabetes may be important for the prediction of CHD risk.