MRP和LRP的表达与食管鳞癌临床病理特征的关系

目的探讨多药耐药相关蛋白(MRP)和肺耐药蛋白(LRP)在食管鳞癌组织中的表达及其与临床病理特征和预后的关系。方法应用Elivision二步免疫组织化学法观察51例食管鳞癌组织和18例癌旁正常黏膜组织(距离癌组织>2cm)中MRP和LRP的表达情况。结果食管鳞癌肿瘤大小在5cm以上者LRP阳性表达率显著高于5cm以下者(P<0.05)。癌组织中MRP和LRP阳性率高于癌旁正常组织,有淋巴结转移者MRP和LRP阳性率高于无淋巴结转移者,MRP和LRP阳性者术后3年生存率低于阴性者,但其差异均无统计学意义。MRP和LRP的表达与患者年龄、肿瘤分化程度、浸润深度、临床分期无统计学相关性。MRP和LRP间无显著性相关。结论MRP和LRP不能作为临床判断食管鳞癌恶性程度、是否转移和预测预后的独立指标,但可提示这些蛋白阳性的患者存在易转移和预后差的趋势。

Relationship between expression of MRP, LRP and clinical pathological features in esophageal squamous cell carcinoma

Objective To investigate the expression of MRP and LRP in esophageal squamous cell carcinoma(ESCC) tissues and the relationship between their expression and clinical pathological features together with prognosis of ESCC. Methods Elivision immunhistochemistry was used to detect the expression of MRP and LRP in 51 ESCC tissues and 18 surrounding noncancerous tissues(the distance is beyond 2cm). Results There was significant correlation between LRP expression and tumor size(P<0.05). The expression rate of MRP or LRP in tumor tissues was higher than that in normal tissues; the positive rate of MRP or LRP in ESCC with lymph node involvement was higher than that without lymph node metastasis. The three-year survival rate of negative patients was higher than that of positive patients, but there was no significant difference. No significant correlation was observed between MRP or LRP expression and patient age, cell differentiation, invasion depth and clinical staging. No significant correlation was observed between MRP and LRP expression. Conclusion The expression of MRP or LRP can't be regarded as an independent marker to predict malignant degree, lymph node involvement and prognosis of ESCC, but it can suggest that there might be the trends of easy metastasis and poor prognosis in patients.