| 大鼠心泵功能的测定与评价 |
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| 引用本文： | 杜晓军,高广道,卢兴,杨继声.大鼠心泵功能的测定与评价[J].西安交通大学学报(医学版),1982(4). |
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| 作者姓名： | 杜晓军 高广道 卢兴 杨继声 |
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| 作者单位： | 西安医学院病理生理教研室 研究生
(杜晓军，高广道)，西安医学院病理生理教研室 副教授
(卢兴)，西安医学院病理生理教研室 副教授(杨继声) |
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| 摘 要： | 本文介绍应用电磁血流计测定大鼠心泵功能的方法。测得20例正常大鼠心脏指数(Cl)为227±7ml/kg/min,心搏量指数(SVl)为0.50±0.02ml/kg,主动脉血流速度(AFV)为3.35±0.17ml/sec,血流加速度(dF/dt)为167±9ml/sec~2,在实验条件下,动物的生理状况在60分钟内基本稳定。容量负荷(VL)使正常鼠Cl、SVl分别增加了193±8%和190±9%,AFV和dF/dt也有明显增加但程度较小(83±5%和64±5%)。正常鼠和心肌梗塞鼠泵功能指标的比较表明,VL时泵功能的改变及其反应曲线有助于更好地估计心功能的损害。
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The Measurement and Evaluation of the Cardiac Pump Function in Rats |
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| Abstract: | The method of measuring cardiac-pump function with electromagneticflowmeter was studied in rats. CI, SVI, AFV and dF/dt measured in 20 nor-mal rats were 227 + 7 ml/kg/min, 0. 50 ± 0. 0.2ml/kg, 3. 35 ± 0. 17ml/secand 167 ± 9 ml/sec~2, respectively. The physiological status of the modelwithin 60 minutes was stable, When volume loading was given, CI and SVI of normal rats were incr-eased by 183 ± 8% and 190 ± 9%, AFV and dF/dt also increased significantlywith less degree (83 ± 8% and 64 ± 5%). The comparision of the pump function indices of the normal and themyocardial infarcted rats showed that during volume loading, the changesof pump function and its response curve were helpful to assess the damageof cardiac function. |
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