突触可塑性与长时程增强现象的研究进展

长时程增强(LTP)是突触传递功能可塑性的重要表现形式,是研究学习与记忆的细胞模型。长持续LTP(LL-LTP)是进行长时记忆研究的细胞模型。近年来的研究资料表明,静寂突触转化为功能性突触可能是LTP维持的重要机制。LTP形成后,可以因生理性刺激或外源性刺激而出现反转。由于LTP具有可反转性和反转输入通路的特异性,采用特异电刺激干预成瘾记忆,以创建不损伤正常脑功能的特异的“成瘾记忆丧失疗法”是我们追寻的目标。

Progress in research of synaptic plasticity and long-term potentiation

Long-term potentiation is an important form of synaptic plasticity and a cellular model for study of learning and memory. Long-lasting long-term potentiation is also a cellular model used in the research of long-term memory. The transformation from silent synapses to the functional ones is probably the important mechanism for the LTP maintenance. After induction, the LTP could be reversed by the physiological or artificial stimulations. Owing to the reversibility of LTP and its input-specific characteristics, it is reasonable to interfere specifically the addiction memory with particular deep brain electrical stimulation without damaging the brain functions.