| 3,6-[二甲氨基]-二苯骈碘杂六环枸橼酸盐对离体豚鼠心脏钙反常的保护作用 |
| |
| 引用本文： | 孙良起,袁素芬,邱培伦,马宏锐.3,6-[二甲氨基]-二苯骈碘杂六环枸橼酸盐对离体豚鼠心脏钙反常的保护作用[J].西安交通大学学报(医学版),1999(1). |
| |
| 作者姓名： | 孙良起 袁素芬 邱培伦 马宏锐 |
| |
| 作者单位： | 现在解放军第１５０医院检验科!洛阳４７１０３１(孙良起)，生物化学教研室!西安７１００６１(袁素芬，马宏锐)，西安医科大学药理教研室(邱培伦) |
| |
| 基金项目： | 国家自然科学基金!No389708392 |
| |
| 摘 要： | 观察了ＩＨＣ－６５对离休豚鼠心脏钙反常的影响，结果表明：ＩＨＣ－６５可使冠脉流出液中ＣＰＫ和蛋白质漏出量比钙反常组明显减少。同时升高心肌ＣＰＫ和ＧＳＨｐｘ活性，减少ＭＤＡ的生成。说明ＩＨＣ－６５对离休豚鼠心脏钙反常有保护作用。其机制可能与抑制脂质过氧化作用有关。
|
| 关 键 词： | 3，6－［二甲氨基］－二苯骈碘杂六环枸橼酸盐 钙反常 CPK GSHpx MDA |
PROTECTIVE EFFECT OF 3, 6-DIMETHAMIDODIBENZOPYRIDONIUM CITRATE (IHC-65) ON CALCIUM PARADOX IN ISOLATED GUINEA PIG HEARTS |
| |
| Sun Liangqi, Yuan Sufen, Qiu Peilun et al.PROTECTIVE EFFECT OF 3, 6-DIMETHAMIDODIBENZOPYRIDONIUM CITRATE (IHC-65) ON CALCIUM PARADOX IN ISOLATED GUINEA PIG HEARTS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(1). |
| |
| Authors: | Sun Liangqi Yuan Sufen Qiu Peilun |
| |
| Institution: | Department of Biochemistry |
| |
| Abstract: | The aim of the present study to assess the protective effect of IHC-65 on calcium paradox in the isolated guinea pig hearts. The resultsshowed that in the treatment with IHC-65 group,the protein leakage and creatine phosphokinase(CPK ) release decreased during reper fusion andIHC-65 can attentuate the decrease in myocardial activity of CPK and glutathione peroxidase (GSHpx)also reduce the generation of malonaldehyde (MDA)in myocardium. Comparison with the calcium para-dox group, these changes were statistically significant. The results of the present study suggests thatcalcium paradox is attenuated by IHC-65 in the isolated guinea pig hearts. The protective mechanismmay be associated with the inhibition of lipid peroxi-dation. |
| |
| Keywords: | 3 6 -dimethamidodibenzopyridonium citrate calcium paradox creatine phosphokinase glu- tathione peroxidase malonaldehyde |
| 本文献已被 CNKI 等数据库收录！ |
