| 复方伪麻黄碱溶液的止咳作用及急性毒性研究 |
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| 引用本文： | 赵秋贤,袁秉祥,赵正航,张大鵾. 复方伪麻黄碱溶液的止咳作用及急性毒性研究[J]. 西安交通大学学报(医学版), 1997, 0(1) |
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| 作者姓名： | 赵秋贤 袁秉祥 赵正航 张大鵾 |
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| 作者单位： | 西安第一临床医学院药剂科!西安710061(赵秋贤，赵正航)，西安基础医学院药理学教研室(袁秉祥)，西安临床医学院(张大鵾) |
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| 摘 要： | 研究了复方伪麻黄碱溶液及其组份对二氧化硫刺激所致小鼠咳嗽反应的影响；分别测定了三个药物及其复方溶液的LD50，并进行了比较分析。结果显示，复方伪麻黄碱溶液具有协同止咳作用。急性毒性研究表明，复方伪麻黄斌溶液的LD50大于右美沙酚，其急性毒性减小。说明复方伪麻黄碱组方合理，比单用右美沙酚安全有效。
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| 关 键 词： | 伪麻黄碱 右美沙芬 扑尔敏 止咳作用 急性毒性 |
THE RELIEVING OF COUGH BY COMPOUND PSEUDOEPHEDRINE AND ITS ACUTE TOXICITY |
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| Zhao Qiuxian,Yuan Bingxiang,Zhao Zhenghang,et al. THE RELIEVING OF COUGH BY COMPOUND PSEUDOEPHEDRINE AND ITS ACUTE TOXICITY[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1997, 0(1) |
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| Authors: | Zhao Qiuxian Yuan Bingxiang Zhao Zhenghang et al |
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| Abstract: | The effects of compound pseudoephedrine (Com), which consists of pseudoephedrine (P), dextromethorphan (D) and chlerpheniramine (C), on cough elicted by sulfur dioxidein mice were studied. The LD50 of the Com and its 3components was determinated and compared witheach other. The results showed that Com could inhibit cough reaction in mice, and its componentshave synergistic action. LD50 of D was the smallest,LD50 of Com > LD50 of D. It's demonstrated thatCom is more effective and safe than D. |
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| Keywords: | pseudoephedrine dextromthorphan chlerpheniramine relieving cough acute toxicity |
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