补钙预防妊高征及对血小板细胞内游离钙浓度的影响

目的　研究补钙对妊高征的预防作用。方法　对 88例有妊高征倾向的孕妇 (随机分为 3组 )自妊娠 2 0～ 2 4周起采用口服不同剂量的钙尔奇 - D(6 0 0 mg、12 0 0 mg)及对照的前瞻性研究 ,用荧光分光光度计测定口服钙前后的血小板游离钙离子浓度 ,并观察妊高征的发生率。结果　经补钙 6 0 0 mg后妊高征发生率 (17.2 4 % )较对照组降低 ,补钙 12 0 0 mg后 ,其妊高征发生率 (6 .90 % )明显低于对照组(2 6 .6 7% ) (P <0 .0 5) ;补钙两组血小板游离钙离子浓度与对照组相比明显降低 (P <0 .0 5)。结论　补充一定量的钙剂可降低血小板游离钙离子浓度 ,对有妊高征倾向的高危孕妇可预防妊高征的发生。

Study on prevention of pregnancy-induced hypertension and effect of platelet intracellular free Ca2+ by calcium supplementation

Objective To research the preventive effect of calcium supplementation on pregnancy induced hypertension(PIH).Methods 88 high risk pregnancy women predisposed to PIH were enrolled in a randomized, controlled clinical trial.From 20 to 24 weeks gestation until delivery they received either 600mg Caltrate D or 1 200mg in the 2 calcium groups and no medicine was given to the controls.PFCa 2+ ] i and ionized calcium in serum were measured and risk of PIH was analyzed.Results ①Calcium supplementation was associated with a significantly decreased risk of PIH, with 6.90% developing PIH in the calcium group with 1 200mg versus 26.67% in the control.There were significant increase in serum ionized calcium.PFCa 2+ ] i decreased significantly in the 2 calcium groups;②PIH incidence in the calcium group with 1 200mg was significantly lower than that of with 600mg .Conclusion This study indicate that calcium supplementation can reduce PFCa 2+ ] i concentration and may play a preventive role in high risk pregnant women predisposed to PIH.