| 复方花刺参粘多糖对大鼠心肌缺血的保护作用 |
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| 引用本文： | 王利民,蔡生业,姚成芳,王丽,周宪宾,王恒孝,蔡茗叶.复方花刺参粘多糖对大鼠心肌缺血的保护作用[J].西安交通大学学报(医学版),2006,27(1):27-28,38. |
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| 作者姓名： | 王利民 蔡生业 姚成芳 王丽 周宪宾 王恒孝 蔡茗叶 |
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| 作者单位： | 山东省医学科学院基础所,山东,济南,250062 |
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| 基金项目： | 国家自然科学基金资助项目(No.30271674)，山东省自然科学基金资助项目(No.Y2002C43) |
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| 摘 要： | 目的观察复方花刺参粘多糖对大鼠急性缺血心肌的保护作用。方法将大鼠随机分为正常对照组、复方花刺参粘多糖组。灌胃3 d后均静脉注射垂体后叶素造成心肌缺血损伤模型,观察两组大鼠心电图ST段偏移及心率失常的发生情况。结果复方花刺参粘多糖能明显缓解垂体后叶素所引起的心电图ST段变化(P<0.05),并能使大鼠心律失常的发生率显著下降(P<0.05)。结论复方花刺参粘多糖对垂体后叶素所致急性缺血心肌具有保护作用。
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| 关 键 词： | 复方花刺参粘多糖 心肌缺血 垂体后叶素 大鼠 |
| 文章编号： | 1671-8259（2006）01-0027-02 |
| 收稿时间： | 2005-06-20 |
| 修稿时间： | 2005-06-202005-09-15 |
Protective effects of stichopus variegates compound on myocardial ischemia rats |
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| Wang Limin,Cai Shengye,Yao Chengfang,Wang Li,Zhou Xianbin,Wang Hengxiao,Cai Mingye.Protective effects of stichopus variegates compound on myocardial ischemia rats[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2006,27(1):27-28,38. |
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| Authors: | Wang Limin Cai Shengye Yao Chengfang Wang Li Zhou Xianbin Wang Hengxiao Cai Mingye |
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| Institution: | Institute of Basic Madicine, Shangdong Academy of Medical Science, Jinan 250062, China |
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| Abstract: | Objective To observe the protective effect of stichopus variegates compound on the myocardial ischemic injury in rats.Methods Wistar rats were randomly divided into stichopus variegates compound group and control group.The models of myocardial ischemia were built in rats with pituitrin after 3-day oral treatment.ST deviation and arrhythmia of ECG in both guoups were observed and compared.Results Stichopus variegates compound benefited the rats with pituitrin-induced acute myocardial ischemia to reverse ST deviation and arrhythmia(P<(0.05)).Conclusion Our results suggest that stichopus variegates compound has a protective action on the experimental myocardial ischemia. |
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| Keywords: | stichopus variegates compound myocardial ischemia pituitrin rat |
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