| DYNAMICAL OBSERVATION OF CARDIO-FUNCTIONAL IMPAIRMENT OF AUTOANTIBODIES AGAINST MITOCHONDRIA AND PEPTIDE IN RATS |
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| 引用本文： | 魏瑾,刘治全,张王刚,刘健. DYNAMICAL OBSERVATION OF CARDIO-FUNCTIONAL IMPAIRMENT OF AUTOANTIBODIES AGAINST MITOCHONDRIA AND PEPTIDE IN RATS[J]. 西安交通大学学报(英文版), 1998, 0(2) |
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| 作者姓名： | 魏瑾 刘治全 张王刚 刘健 |
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| 作者单位： | Department of Cardiology，First Clinical Medical College，Xi'an Medical University，Xi'an 710061 |
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| 摘 要： | Autoantibodiesagainst-theadeninenecleotidetranslocator(ANT)mightplayanimportantroleinthedevelopmentofviralmyocarditis(VMC)andidiopathicdilatedcardiomyopathy(DCM)tl].ThebestwaytodescribethepathogenesisofantiANT-antibodiesistoimmuneanimalswithANT.However,difficultiesinthepreparationandstorageofnativeANTproteinsinfluencedfurtherinvestigation.Recently,accordingtotheaminoacidsequencesanddistributionofantigenicdeterminantsofANT,wesynthesizedapeptidecontaining'oneoftheantigenicdeterminantsof…
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DYNAMICAL OBSERVATION OF CARDIO-FUNCTIONAL IMPAIRMENT OF AUTOANTIBODIES AGAINST MITOCHONDRIA AND PEPTIDE IN RATS |
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| Wei Jin,Liu Zhiquan,Zhang Wanggang,Liu Jian. DYNAMICAL OBSERVATION OF CARDIO-FUNCTIONAL IMPAIRMENT OF AUTOANTIBODIES AGAINST MITOCHONDRIA AND PEPTIDE IN RATS[J]. Academic Journal of Xi’an Jiaotong University, 1998, 0(2) |
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| Authors: | Wei Jin Liu Zhiquan Zhang Wanggang Liu Jian |
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| Abstract: | 27 rats were immunized with synthetic ANT peptide. Antibody titers in sera and heartfunctions were measured at day 14, 28 and 42 arter the latest immunization. The results showed thatIn the 27 rats immuuized with the ANT Peptide, 63% (17/27) showed marked increasing or specificanti-ANT-Peptide antibody titers in sera. The highest positive rate of antibodies in sera is on the 28th day after the latest immunization. Remarkabie impairment of cardiac functions was observed simultaneously. Correlaled analysis indicates that the degree of the declined cardiac function relatedclosely with the levels of antibody titers. It is indicated that anti-ANT-antibody is a specific,Pathogenic autoantibody to heart. The synthetic ANT peptide we select could replace the native ANTprotein in further studies of the pathogenesis of antiboies against ANT. |
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| Keywords: | myocardiol disecase ADP/ATP carrier synthetic peptide autoantibody |
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