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| 肝癌特异γ-谷氨酰转肽酶同功酶Ⅱ活性检测及其临床价值 | |
| 引用本文： | 苗爱莲,李军,魏曙亚,侯蓉,原荣,王香林.肝癌特异γ-谷氨酰转肽酶同功酶Ⅱ活性检测及其临床价值[J].西安交通大学学报(医学版),2003,24(1):85-87. |
| 作者姓名： | 苗爱莲 李军 魏曙亚 侯蓉 原荣 王香林 |
| 作者单位： | 1. 西安交通大学第一医院检验科,西安,710061 2. 陕西省肿瘤医院基础研究室,西安,710061 3. 西安交通大学第二医院检验科,西安,710004 |
| 摘 要： | 目的 探讨患者血清肝癌特异γ 谷氨酰转肽酶同功酶Ⅱ (GGTⅡ )活性与肝癌生物学行为的相关性及其临床价值。方法 用硝酸纤维膜特异免疫吸附法 (NSIA)对患者血清中GGTⅡ进行定性检测。结果 原发性肝癌(PHC)检测敏感性为 83 .77% ,特异性为 98.0 4% ,转移性肝癌 (MLT)诊断阳性率为 7.5 5 % ,对AFP阴性的PHC患者检测阳性率为 65 .91%。结论 NSIA检测GGTⅡ简便、快速、微量、灵敏、经济 ,可用于PHC的辅助诊断、鉴别诊断和早期发现 ,也可作为其他肝癌标志物的补充 |
| 关 键 词： | 原发性肝癌 GGTⅡ 硝酸纤维膜特异免疫吸附法 |
| 文章编号： | 1671-8259(2003)01-0085-03 |
| 修稿时间： | 2002年7月9日 |
Clinical value of the activity of γ-glutamyltranspeptidase isoenzymes Ⅱ in serum of patients with liver cancer |
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| Miao Ailian,Li Jun,Wei Shuya,Hou Rong,Yuan Rong,Wang Xianglin.Clinical value of the activity of γ-glutamyltranspeptidase isoenzymes Ⅱ in serum of patients with liver cancer[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2003,24(1):85-87. | |
| Authors: | Miao Ailian Li Jun Wei Shuya Hou Rong Yuan Rong Wang Xianglin |
| Abstract: | Objective To study the clinical application of the activity of γ-glutamyltranspeptidase isoenzymes Ⅱ(GGTⅡ) in serum of patients with liver cancer. Methods The activity of GGTⅡ in serum was detected by rapid nitrate cellulose membrane immunosorbent assay. Results The sensitivity and specificity of detection for primary hepatocellular cancer (PHC) were 83.77% and 98.04% and the rates of positive detection for metastatic liver tumor (MLT) and PHC with AFP(-) were 7.55% and 65.91%. Conclusion This new assay is rapid, simple, sensitive and specific and can be used to assist diagnosis of PHC and supplement other tumor markers of liver cancer. |
| Keywords: | primary hepatocellular carcinoma (PHC) γ-glutamyltranspeptidase isoenzymes Ⅱ nitrate cellulose membrane immunosorbent assay |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |