FPSA/TPSA比值在前列腺癌诊断中的意义

目的　评价FPSA/TPSA比值在前列腺癌诊断中的作用。方法　 32例前列腺癌 (PC)及97例前列腺良性增生 (BPH)患者 ,经活检穿刺或 (和 )手术病理确诊 ,采用酶联免疫方法测定血清中总前列腺特异性抗原 (TPSA) ,游离前列腺特异性抗原 (FPSA)浓度 ,计算FPSA/TPSA(F/T)比值。结果　TPSA浓度在 4.0～ 1 0 .0 μg·L- 1 范围时 ,其浓度两组间无显著性差异 (P >0 .0 5 ) ,而F/T比值则有显著性差异 (P <0 .0 1 ) ;测得F/T比值在 0 .2 5水平时 ,总有效率最大( 62 .9% )。结论　TPSA单独作为前列腺癌和前列腺良性增生鉴别诊断的指标存在局限性。当TPSA水平在 4.0～ 1 0 .0 μg·L- 1 范围内 ,应用F/T比值较PSA为优。F/T比值在 0 .2 5界值时诊断PC和BPH最有效

The role of the ratio of free PSA and total PSA in diagnosing prostate carcinoma

Objective To evaluate the effect of the ratio of free PSA and total PSA (F/T) in the diagnosis of prostate carcinoma (PC).Methods In a series of histologically confirmed 97 benign prostate hyperplasia (BPH) patients and 32 prostate cancer patients, researchers had measured the serum TPSA, FPSA and the ratio of free PSA and total PSA with the enzyme immunoassay of them for the quantitative determination.Results If the value of TPSA was between 4.0 and 10.0?μg·L -1 , there was no significant difference between the patients with PC and BPH ( P >0.05), but the percentage of free PSA and total PSA was lower in patients with PC than that in patients with BPH ( P <0.01). If the ratio of free PSA and total PSA was 0.25, the total validity for diagnosis PC was 62.9%.Conclusion The value of the TPSA is a restrictive marker for the differential diagnosis of PC and BPH. The value of 0.25 of the ratio of free PSA and total PSA is a maximum validity for diagnosing PC and BPH. The ratio of free PSA and total PSA is superior to TPSA in diagnosing PC if total PSA is between 4.0 and 10.0?μg·L -1 .