中药甘露1号抑瘤作用的研究 |
| |
引用本文: | 董德全,田颖,田琼,庄稼,朱金萍,龙晓瑶.中药甘露1号抑瘤作用的研究[J].西安交通大学学报(医学版),2001,22(2):151-153. |
| |
作者姓名: | 董德全 田颖 田琼 庄稼 朱金萍 龙晓瑶 |
| |
作者单位: | 西安交通大学肿瘤研究所,西安交通大学医院 |
| |
基金项目: | 陕西自然科学基金资助课题(97sm65) |
| |
摘 要: | 目的 探讨中药甘露 1号的抑瘤作用及其机制。方法 采用在体、离体动物实验观察中药甘露 1号煎剂对接种S 1 80的LACA小鼠、TCR小鼠的抑瘤作用及对SMMC 772 1人肝癌细胞生长的抑制作用。结果 该煎剂对接种S 1 80的LACA小鼠、TCR小鼠的抑瘤率为 32 3% 55 4% (P <0 0 1 )。但甘露 1号 +MTX(氨甲喋呤 )复合组的抑瘤率不高于单用MTX的抑瘤效果。在细胞培养实验中 ,其对SMMC 772 1人肝癌细胞生长的抑制随其浓度的提高而增加 ,呈线性关系。结论 甘露 1号煎剂对在体动物实验和细胞实验均显示了抑制肿瘤生长的作用
|
关 键 词: | 甘露1号 抗癌作用 S-180 SMMC-7721 |
文章编号: | 0258-0659(2001)02-0151-03 |
修稿时间: | 2000年8月14日 |
An experimental study of the anti-tumor drug Ganlu I decoction |
| |
Abstract: | Objective In order to explore how the Ganlu I decoction repress the growth of tumor cell. Methods We made some experiments: Ganlu I inhibited the tumor mass growth on mice in vivo;and inhibited the growth of SMME 7721 human liver tumor cells.Results The study showed that Gaulu I has effect of repressing the tumor mass growth,the inhibited ratio from 32.3% to 55.4% on LACA and TCR mice in vivo ( P<0.01 ).In Ganlu I MTX treated mice,the inhibited ratio of tumor growth didn't higher than that of only MTX4 treated mice. In vitro Gaulu I restrained the growth of human liver tumor cells SMM 7721, the effect related to its concentration. Conclusion Ganlu I has certain effects of anti tumor on mice in vivo and on cell cultrue in vitro. |
| |
Keywords: | Ganlu I decoction osteogenic cancer liver cancer cell rhabdomyoma hematoposis |
本文献已被 万方数据 等数据库收录! |
|