Abstract: | Gastrin, somatostatin, glucagon ingastric carcinoma taken from 48 cases were observedby immunohistochemical labeling methods. The results revealed that gastrin in 14 cases was positive(29. 2%), somatostatin in 9 cases was positive(18. 7% ), both gastrin and somatostatin were positive in 6 cases (12. 5% ). The positive rate of endocrine cells in undifferential carcinoma was significantly higher than that of hyperdifferentiatedcarcinoma. Serosa infiltrative rate was 13/14 (92. 9% ) and lymphatic metastases rate was if/14(78. 5% ) in gastrin positive group. The two rateswere prominently higher than those in gastrin negtive group (P < 0. 01 ). In somatostatin positivegroup, serosa infiltrative rate was 6/9 (66. 7 % ) andlymphatic metastases rate was 4/9 (44. 4%), therewas no significant difference compared with those ofsomatostatin negtive group (Tff$465 M)(I&$457 N ) (P >0. 05). The results suggestthat gastrin might accelerate the proliferation ofcarcinoma cells, the more active the carcinomacells, the more strongly invasiving and highermetastases rate. The roles of somatostatin in gastric carcinoma need further investigation. |