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| 普乐康对HIV/AIDS患者细胞免疫功能的影响 | |
| 引用本文： | 马慧群,田中伟,冯捷,宋向凤,曹毓琳,周心芳,曹二营.普乐康对HIV/AIDS患者细胞免疫功能的影响[J].西安交通大学学报(医学版),2004,25(6):608-609,613. |
| 作者姓名： | 马慧群 田中伟 冯捷 宋向凤 曹毓琳 周心芳 曹二营 |
| 作者单位： | 1. 西安交通大学第二医院皮肤科,陕西西安,710004 2. 西安交通大学第二医院皮肤科,陕西西安,710004;新乡医学院免疫学教研室,河南新乡,453003 3. 新乡医学院免疫学教研室,河南新乡,453003 4. 达海通(蕲春)药物科技发展有限公司,湖北武汉,420000 5. 河南省上蔡县齐海乡卫生院,河南上蔡,463800 |
| 摘 要： | 目的 探讨中药普乐康对HIV/AIDS患者细胞免疫功能的影响。方法 普乐康治疗前后 ,采用PHA体外诱导淋巴细胞增殖 ,观测治疗前后淋巴细胞增殖能力的变化 ,并测定血清细胞因子IL 2和IFN γ浓度的变化 ;用LDH释放法测定NK和LAK细胞的杀伤活性 ,对结果进行统计学处理。结果 用药后HIV/AIDS患者血液的淋巴细胞对PHA诱导的增殖能力、血清IL 2和IFN γ水平均明显高于治疗前 (P均 <0 .0 5 ) ;NK和LAK细胞的杀伤活性亦明显高于治疗前 (P <0 .0 5 )。结论 普乐康可以改善HIV/AIDS患者细胞免疫功能紊乱状态 ,有助于患者机体的康复。 |
| 关 键 词： | HIV/AIDS 细胞免疫 NK细胞 LAK细胞 白细胞介素2 干扰素γ |
| 文章编号： | 1671-8259(2004)06-0608-02 |
Effects of PULEKANG on the immunological function in patients with HIV/AIDS |
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| Ma Huiqun,Tian Zhongwei,Feng Jie,Song Xiangfeng,Cao Yulin,Zhou Xinfang,Cao Erying.Effects of PULEKANG on the immunological function in patients with HIV/AIDS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2004,25(6):608-609,613. | |
| Authors: | Ma Huiqun Tian Zhongwei Feng Jie Song Xiangfeng Cao Yulin Zhou Xinfang Cao Erying |
| Abstract: | Objective To investigate the effects of PULEKAN G on cellular immunity in serum in patients with HIV/AIDS. Methods Before and after treatment with PULEKANG, PHA was u sed to induce the proliferation of lymphocytes. The proliferative ability of lym phocytes was measured with MTT assay. The serum levels of IL-2/IFN-γ were detected with ELISA assay. The activities of NK and LAK cells were measured wit h lactate dehydrogenase (LDH) methods. Results Compared with those of post-treatment, the prolife rative ability of lymphocytes, the serum levels of IL-2 and IFN-γ, the ac tivities of NK and LAK cells were significantly lower in the patients with HIV/A IDS before treatment. Conclusion PULEKANG can improve the dysfunction of cellular immunity of the patients with HIV/AIDS. |
| Keywords: | HIV/AIDS cellular immunity NK cell LAK cell IL -2 IFN-γ |
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