| Abstract: | Objective Tumors with accelerated growth or high malignancy are thought to undergo active angiogenesis. Whereas by far, there is few study concerning the combination of MIB-1 proliferation index (MIB-1 PI) and tumor angiogenesis in carcinomas to show their significance in relate to clinicopathological parameters. In the present study, we evaluated the significance of MIB-1 PI and angiogenesis in early stage of gastric cancer. Our focus was especially on the combination of MIB-1 PI and angiogenesis in relate to lymph node metastasis. Methods Specimens from 95 patients with early gastric cancer were studied by means of immunohistochemistry using monocional MIB-1 and factor Ⅷ related antigen antibodies. Results The mean MIB-1 PI and microvessel count were 22.9％ and 34.7,respectively. The MIB-1 PI did not correlate with microvessei count. Both correlated with depth of tumor invasion,lymphatic vessel invasion and lymph node metastasis. Multivariate analysis showed that combined high MIB-1 PI/hypervascularity, as well as lymphatic vessel invasion and tumor size were independent factors that impact on lymph node metastasis. Conclusion A combination of the high MIB-1 PI/hypervascularity is a factor that related to lymph node metastasis in early gastric cancer. |
