| 靶向间皮角质细胞生长因子对术后腹膜粘连的预防作用 |
| |
| 引用本文： | 纪明明,王康,仇广林,魏光兵,赵伟.靶向间皮角质细胞生长因子对术后腹膜粘连的预防作用[J].西安交通大学学报(医学版),2011,32(4):489-492. |
| |
| 作者姓名： | 纪明明 王康 仇广林 魏光兵 赵伟 |
| |
| 作者单位： | 西安交通大学医学院第一附属医院普通外科,陕西西安,710061 |
| |
| 摘 要： | 目的研究角质细胞生长因子(KGF)对大鼠腹膜粘连形成的预防作用及对腹膜粘连组织中组织纤溶酶原激活物(tPA)和纤溶酶原激活物抑制剂(PAI-1)表达的影响。方法 SD大鼠30只,随机分为3组(n=10),分别为KGF组、模型组和假手术组。7 d后处死大鼠,并参照修改后的Leach等评分系统评价粘连程度。光镜观察组织形态学变化,并用免疫组化SP法测定腹膜粘连组织中tPA和PAI-1表达情况。结果 KGF组粘连总评分结果(4.8±0.92)明显低于模型组(7.6±1.35)(P<0.01),免疫组化染色示KGF组tPA表达水平(88.41±3.92)明显高于模型组(111.63±4.04)和假手术组(100.91±1.57)(P<0.01),而PAI-1表达水平在3组之间无差异(P>0.05)。结论 KGF通过促使损伤处腹膜再生及纤溶能力恢复达到预防腹膜粘连形成,提示间皮再生可能是预防粘连形成的有效途径。
|
| 关 键 词： | 角质细胞生长因子 间皮 腹膜粘连 预防 腹膜纤溶系统 组织纤溶酶原激活物 纤溶酶原激活物抑制剂 |
The protective effects of keratinocyte growth factor targeted mesothelium on the postoperative peritoneal adhesions |
| |
| JI Ming-ming,WANG Kang,QIU Guang-lin,WEI Guang-bing,ZHAO Wei.The protective effects of keratinocyte growth factor targeted mesothelium on the postoperative peritoneal adhesions[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2011,32(4):489-492. |
| |
| Authors: | JI Ming-ming WANG Kang QIU Guang-lin WEI Guang-bing ZHAO Wei |
| |
| Institution: | JI Ming-ming,WANG Kang,QIU Guang-lin,WEI Guang-bing,ZHAO Wei(Department of General Surgery,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710061,China) |
| |
| Abstract: | Objective To investigate the effects of keratinocyte growth factor(KGF) by promoting mesothelial regeneration on the prevention of peritonea1 adhesion formation in rats and expressions of tissue plasminogen activator(tPA) and plasminogen activator inhibitor type 1(PAI-1) in peritonea1 adhesion tissues.Methods Thirty SD rats were randomly assigned to KGF group,model group and sham-operation group,each consisting of 10 rats.All rats were killed 7 days later and the adhesion degree was evaluated by modified Le... |
| |
| Keywords: | keratinocyte growth factor mesothelium peritoneal adhesion prevention peritoneal fibrinolytic system tissue plasminogen activator(tPA) plasminogen activator inhibitor type 1(PAI-1) |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
