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| 锰的心血管毒性 | |
| 引用本文： | 姜岳明,张振明,迟晓文.锰的心血管毒性[J].铁道劳动安全卫生与环保,2001,28(4):251-254. |
| 作者姓名： | 姜岳明 张振明 迟晓文 |
| 作者单位： | 1. 广西医科大学劳动卫生与毒理学教研室,广西,南宁,530021 2. 梧州市卫生防疫站,广西,梧州,543002 3. 桂林市卫生防疫站,广西,桂林,541001 |
| 摘 要： | 体内外实验表明，锰能迅速富集在动物心脏，引起心脏收缩功能降低和血压下降，这可能与心肌线粒体受损和Ca^2 通道受阻有关。迄今为止，锰的心血管毒性实验研究主要局限于体外试验、急性和亚急性毒性试验，尚缺乏慢性毒性试验的资料，其毒作用性质及其转归过程尚未完全明了，有必要深入探讨。 |
| 关 键 词： | 锰 心血管功能 毒性 心脏 血管 毒理 |
| 文章编号： | 1003-1197(2001)04-0251-04 |
| 修稿时间： | 2001年9月14日 |
Manganese Cardiovascular Toxicity |
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| JIANG Yue ming\ ,ZHANG Zhen\|ming\ ,CHI Xiao\|wen\.Manganese Cardiovascular Toxicity[J].Railway Occupational Safety Health & Environmental Protection,2001,28(4):251-254. | |
| Authors: | JIANG Yue ming\ ZHANG Zhen\|ming\ CHI Xiao\|wen\ |
| Institution: | JIANG Yue ming\ 1,ZHANG Zhen\|ming\ 2,CHI Xiao\|wen\ 3 |
| Abstract: | It is shown that manganese can quickly accumultate in animal heart and lead to acute and subacute cardiovascular functional depression and hypotension, which is associated with the myocardial injured mitochondrion and blockage of the slow calcium channel. Until now, the experimental studies on Mn cardiovascular toxicity are mainly limited in vitro test, acute and subacute toxicity, which is short of data on chronic toxicity. The properties of Mn cardiovascular toxicity and its chang result are not understood completely, which is in need of further studies. |
| Keywords: | manganese cardiovasclar function toxicity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |