Unexpected roles of long non-coding RNAs in cancer biology |
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| Authors: | Ying Qi Ya-ni Kang Xiao-dong Zhao |
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| Institution: | 1. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiaotong University, Shanghai, 200240, China
2. School of Biomedical Engineering and Bio-ID Research Center, Shanghai Jiaotong University, Shanghai, 200240, China
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| Abstract: | Recent studies show that long non-coding RNAs (lncRNAs) play important roles in the regulation of various biological processes, including chromatin remodeling, dosage-compensation, imprinting, and epigenetic regulation. Aberrant expression of lncRNAs is involved in many complex human diseases, including cancer. In this review, we summarized recent progress on lncRNAs detection methodology with emphasis on their functions and potential implication in cancer diagnosis and therapy. |
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