| HLA-I类基因多态性与白血病易感性的关联性研究 |
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| 引用本文： | 周兰霞,赵丽.HLA-I类基因多态性与白血病易感性的关联性研究[J].西安交通大学学报(医学版),2007,28(4):406-408. |
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| 作者姓名： | 周兰霞 赵丽 |
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| 作者单位： | 兰州大学第一医院中心实验室,甘肃兰州,730000 |
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| 基金项目： | 甘肃省自然科学基金暨中青年基金 |
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| 摘 要： | 目的探讨白血病易感性与HLA-I类基因多态性之间的关联性,寻找白血病的易感基因。方法采用序列特异性寡核苷酸探针杂交技术(PCR-SSO)对65例白血病患者和48例正常对照组健康者进行HLA-A、B基因分型。结果在等位基因HLA-A、B中,白血病患者的HLA-A01、B38基因的基因频率高于正常对照组(P<0.05),而HLA-A11基因的基因频率明显下降(P<0.05)。结论基因A01、B38对白血病有遗传易感作用,而基因A11对白血病有遗传拮抗作用。
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| 关 键 词： | 白血病 多态性 |
| 文章编号： | 1671-8259（2007）04-0406-03 |
| 修稿时间： | 2007-01-16 |
Correlation between gene HLA-class I polymorphism and susceptibility to leukemia |
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| Zhou Lanxia,Zhao Li.Correlation between gene HLA-class I polymorphism and susceptibility to leukemia[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2007,28(4):406-408. |
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| Authors: | Zhou Lanxia Zhao Li |
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| Institution: | The Core Laboratory, The First Hospital of Lanzhou University, Lanzhou 730000, China |
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| Abstract: | Objective To explore the correlation between gene HLA-class I polymorphism and susceptibility to leukemia in Chinese Gansu Han people and search for the genes susceptible to leukemia.Methods HLA-A and B alleles polymorphism in 65 patients with leukemia and 48 normal subjects were determined by PCR with sequence specific oligucleotide probe(PCR-SSO).Results The allele frequencies of HLA-A01 and B38 were increased (P<0.05),while the allele frequencies of HLA-A11 were decreased in patients with leukemia(P<0.05).Conclusion HLA-A01 and B38 alleles seem to contribute to the genetic susceptibility to leukemia,while HLA-A11 seems to contribute to its genetic resistance. |
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| Keywords: | HLA PCR-SSO |
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