| DL-四氢巴马汀和青藤碱对兔输卵管平滑肌活动的影响 |
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| 引用本文： | 雷汉琴,徐元秀,鞠敏,赵更生. DL-四氢巴马汀和青藤碱对兔输卵管平滑肌活动的影响[J]. 西安交通大学学报(医学版), 1993, 0(3) |
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| 作者姓名： | 雷汉琴 徐元秀 鞠敏 赵更生 |
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| 作者单位： | 西安医科大学药理学教研室，西安医科大学药理学教研室，西安医科大学药理学教研室，西安医科大学药理学教研室 西安 710061，西安 710061，西安 710061，西安 710061 |
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| 基金项目： | 国家自然科学基金 No.3860855 |
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| 摘 要： | 作者观察了两种中药钙拮抗剂DL—四氢巴马汀和青藤碱对兔输卵管平滑肌活动及对卵子运行的影响。结果表明:两药均可明显抑制兔离体输卵管峡部肌收缩活动,使其频率、振幅、张力均降低,收缩活动曲线面积明显减少,并能抑制去甲肾上腺素诱导的收缩效应。在iv HCG 48 h后,具有延缓兔输卵管内卵子运行的作用。结果提示,抑制平滑肌活动可能是这两种药物延缓卵运行的主要原因之
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| 关 键 词： | DL-四氢巴马汀 青藤碱 输卵管平滑肌 卵转运 |
THE EFFECT OF DL-TETRAHYDROPALMATINE AND SINOMEMINE ON THE MOTILITY OF OVIDUCT SMOOTH MUSCLE IN RABBITS |
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| Lei Hanqin,Xu Yuanxiu,Ju Ming,et al. THE EFFECT OF DL-TETRAHYDROPALMATINE AND SINOMEMINE ON THE MOTILITY OF OVIDUCT SMOOTH MUSCLE IN RABBITS[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1993, 0(3) |
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| Authors: | Lei Hanqin Xu Yuanxiu Ju Ming et al |
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| Affiliation: | Lei Hanqin,Xu Yuanxiu,Ju Ming,et al Department of Pharmacology |
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| Abstract: | The effects of DL-tetrahydropalmatine andsinomemine on the activity of oviduct smooth mus-cle and ovum transport in rabbits are reported inthis paper. The results indicate that the two a-gents apparently inhibit the contractile activity ofoviduct isthmic smooth muscle of rabbit in vitroand decrease the frequency, amplitude, tensionand curve areas of the contraction. The contractileffect induced by noradrenaline is also inhibited re-markbly by them. In addition, DL-THP and Sino.can delay ovum transport in rabbit oviduct after ivHCG 48 h. It is suggested that the inhibition ofactivity of oviduct smooth muscle may be one ofthe important causes of delaying egg transportcaused by the two agents. |
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| Keywords: | DL-tetrahydropalmatine sinomemine oviduct smooth muscle ovum transport |
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