涎腺粘液表皮样癌中角蛋白、波形蛋白和S-100蛋白的定位研究

用免疫组化法对37例涎腺粘液表皮样癌中角蛋白、波形蛋白和S-100蛋白定位进行观察,发现表皮样细胞和中间细胞呈角蛋白、波形蛋白和S-100蛋白阳性,粘液细胞呈角蛋白和S-100蛋白阳性。肿瘤团块中有些散在梭形、星形或不规则形细胞呈S—100蛋白强阳性;囊腔和腺管腔面细胞基部也有梭形、扁平或不规则形细胞呈S-100蛋白强阳性及波形蛋白和角蛋白阳性。在肿瘤细胞索外周还发现些梭形或扁平细胞是S-100蛋白、波形蛋白和角蛋白阳性。提示,涎腺粘液表皮样癌为上皮源性肿瘤,实质内存在肌上皮细胞,肌上皮细胞与中间细胞似有直接关联。

THE IMMUNOHISTOCHEMICAL STUDY ON LOCALIZATION OF KERATIN VIMENTIN AND S-100 PROTEIN IN MUCOEPIDERMOID CARCINOMA

The localization of keratin, vimentin and S-100protein in 37 cases of mucoepidermoid carcinomawere studied with immunohistochemistry. The re-sult showed that epidermoid cells and intermediatecells were revealed keratin, vimentin and S-100protein positive, mucous cells presented keratinand S-100 protein positive, and endothelial cell ofblood vessels only showed vimentin positive. Incarcinoma S-100 protein strong positive reactionalso appeared in some scattered spindle, star or ir-regular cells. A lot of spindle, flat or irregularcells which located on the base of cystic lumen lu-minal cell and duct luminai cell were revealed notonly S-100 protein strong positive but also vi-mentin and keratin positive. In addition, we alsofound some spindle or flat cells on the peripheralarea of tumor cord also have kerarin, vimentin andS-100 protein positive. The above results suggest-ed that salivary gland mucoepidermoid carcinomaactually is the tumor of epithelial origin in whichexisted myoepithelial cell Therefore, there appearsdirect relationship between myoepithelial cell andintermediate cell.