| 雷公藤甲素对小鼠移植皮片存活期MLR及IL-2水平的影响 |
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| 引用本文： | 刘湘玲,雷岁合,董晓慧,李广运,鲍德虎.雷公藤甲素对小鼠移植皮片存活期MLR及IL-2水平的影响[J].西安交通大学学报(医学版),1999(2). |
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| 作者姓名： | 刘湘玲 雷岁合 董晓慧 李广运 鲍德虎 |
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| 摘 要： | 利用我们已建立的动物模型观察雷公藤甲素对实验鼠移植皮片存活期、ＭＬＲ及ＩＬ－２水平的影响。结果表明，雷公藤甲素联合ＤＳＴ组皮片存活延长，ＭＬＲ和ＩＬ－２水平明显下降（Ｐ＜０．０１，Ｐ＜０．０５）；当其同时联合ＤＳＴ和ＡＴＳ，皮片存活期明显延长（Ｐ＜０．０５），ＭＬＲ和ＩＬ－２进一步下降（Ｐ＜０．０１）。提示雷公藤甲素在临床器官移植中可能具有一定应用价值。
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| 关 键 词： | 雷公藤甲素 器官移植 移植排斥反应 |
THE EFFECTS OF TRIPTOLIDE ON MOUSE SKIN GRAFTSURVIVAL PERIOD ,MLR AND IL2 LEVEL |
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| Liu Xiangling,Lei Suihe,Dong Xiaohui et al.THE EFFECTS OF TRIPTOLIDE ON MOUSE SKIN GRAFTSURVIVAL PERIOD ,MLR AND IL2 LEVEL[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(2). |
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| Authors: | Liu Xiangling Lei Suihe Dong Xiaohui |
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| Institution: | Department of New Pharmacy Products Research |
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| Abstract: | The effects of TRIPTOLIDE(TL) on mouse skin graft survival period,MLR and IL2 level were observed with our established animal model.The results showed that TL could prolong skin graft survival period slightly,but depress MLR and IL2 significantly when combined with donor specific transfusion (DST).However ,when TL combines with both DST and antithymocyte serum (ATS),the skin graft can survive for a longer time (P<0.05);MLR and IL2 level continuously decline(P<0.01).These results indicate that TL may have certain value in clinical organ transplantation. |
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| Keywords: | triptolide organ transplantation graft rejection |
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