| EFFECT OF MIFEPRISTONE (RU486)ON MARKERS OF ENDOMETRIAL RECEPTIVITY |
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| 作者姓名： | 武捷 王龙生 程捷 王介东 |
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| 作者单位： | Department of Histology & Embryology，Department of Histology & Embryology，National Research Institute for Family Planning，National Research Institute for Family Planning Medical School of Xi'an Jiaotong University，Xi'an 710061，China，Medical School of Xi'an Jiaotong University，Xi'an 710061，China，Beijing，100081，China，Beijing，100081，China |
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| 基金项目： | ThisresearchwassupportedbytheWorldHealthOrganization |
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| 摘 要： | Mifepristone (RU4 86 )hasbeenusedinclinicasaneffectiveemergencycontraception (EC)meth od .And ,areductionfrom 6 0 0mgto 10mgdidnotinfluenceefficacy1] .However ,themechanismisnotclear .Inpractice ,unprotectedsexualintercoursecanoccuratanytimeinamenstrualcycle .AnidealECwouldbeonewhichcouldblockovulationandimplantation .Thus ,theeffectofEContherecep tivityoftheendometriumiscriticalforitseffec tiveness .Implantationofthehumanblastocystintheen dometriumisconsideredtobeinitiatedbyadia loguebet…
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EFFECT OF MIFEPRISTONE (RU486) ON MARKERS OF ENDOMETRIAL RECEPTIVITY |
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| Wu Jie,Wang Longsheng,Cheng Jie ,Wang Jiedong.EFFECT OF MIFEPRISTONE (RU486)ON MARKERS OF ENDOMETRIAL RECEPTIVITY[J].Academic Journal of Xi’an Jiaotong University,2003,15(1). |
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| Authors: | Wu Jie Wang Longsheng Cheng Jie Wang Jiedong |
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| Institution: | 1. Department of Histology & Embryology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China
2. National Research Institute for Family Planning, Beijing, 100081, China |
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| Abstract: | Objective To study the effect of single and low dose of RU486 on endometrial receptivity of healthy women. Methods A total of 5 healthy women were followed for one control and one treatment cycle. In the treatment cycle, a dose of 10 mg RU486 was administered on day luteinizing hormone (LH)-2. In both the control and treatment cycle, an endometrial biopsy was obtained on LH+7. These biopsies were assessed by immunohistochemical analysis to find the difference in expression of integrins and progesterone receptor (PR) between the control and treatment cycle. Results The treatment with RU486 increased the expression of α1 and α4 subunits of integrin in glandular epithelial cells, but did not influence β3 subunit. Moreover, the normal down-regulation of PR in epitherial cell nuclei was inhibited by 10 mg RU486. Conclusion Single dose of 10 mg RU486 impairs the establishment of endometrial receptivity on time. |
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| Keywords: | mifepristone (RU486) integrin progesterone receptor (PR) endometrial receptivity |
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