| FUCOIDIN INHIBITS OXIDIZED LOW DENSITY LIPOPROTEIN FROM INDUCING HUMAN PERIPHERAL BLOOD MONOCYTE EXPRESSION OF PROINFLAMMATORY CYTOKINES mRNA |
| |
| 引用本文： | 雷新军,马爱群,任冰稳,耿涛,张葳,白玲. FUCOIDIN INHIBITS OXIDIZED LOW DENSITY LIPOPROTEIN FROM INDUCING HUMAN PERIPHERAL BLOOD MONOCYTE EXPRESSION OF PROINFLAMMATORY CYTOKINES mRNA[J]. 西安交通大学学报(英文版), 2003, 15(1) |
| |
| 作者姓名： | 雷新军 马爱群 任冰稳 耿涛 张葳 白玲 |
| |
| 作者单位： | Department of Cardiology，Department of Cardiology，Department of Cardiology，Department of Cardiology，Department of Cardiology，Department of Cardiology First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China |
| |
| 基金项目： | ThisworkwassupportedbytheActionProjectFoundationofXi’anJiaotongUniversity |
| |
| 摘 要： | Researcheshavealreadydemonstratedthatscav engerreceptorclassA(SR A)isabletobindoxidizedlowdensitylipoprotein(OxLDL)withhighaffinityandisoneofthemainreceptormediatingmurinemacrophagetouptakeOxLDL[1] .Itisalsoexpressedinhumanperipheralbloodmonocyte[2 ] andathero scleroticlesions[3 ] .However ,functionsofSR Ainmediatinghumanperipheralbloodmonocytetoup takeOxLDLaswellaspromotingtheatheroscleroticimmuno pathologicallesioninthelocalbloodvesselarestillunclear .Soforthepurposeofstudyingthefunc…
|
FUCOIDIN INHIBITS OXIDIZED LOW DENSITY LIPOPROTEIN FROM INDUCING HUMAN PERIPHERAL BLOOD MONOCYTE EXPRESSION OF PROINFLAMMATORY CYTOKINES mRNA |
| |
| Lei Xinjun,Ma Aiqun ,Ren Bingwen,Geng Tao,Zhang Wei,Bai Ling. FUCOIDIN INHIBITS OXIDIZED LOW DENSITY LIPOPROTEIN FROM INDUCING HUMAN PERIPHERAL BLOOD MONOCYTE EXPRESSION OF PROINFLAMMATORY CYTOKINES mRNA[J]. Academic Journal of Xi’an Jiaotong University, 2003, 15(1) |
| |
| Authors: | Lei Xinjun Ma Aiqun Ren Bingwen Geng Tao Zhang Wei Bai Ling |
| |
| Affiliation: | Department of Cardiology, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China |
| |
| Abstract: | Objective To study the significance of scavenger receptor class A(SR-A)in mediating human peripheral blood monocyte to uptake oxidized low density lipoprotein(OxLDL) and promoting the atherosclerotic immuno-pathological lesion in the local blood vessel. Methods With the Digoxenin-labeled Oligonucleotide-probes In situ Hybridization, this research investigated the effects of OxLDL on the mRNA expression of proinflammatory cytokines including MCP-1, bFGF, PDGF and IL-10 in the human peripheral blood monocyte and whether fucoidin, a peculiarly inhibitory ligand for SR-A, would influence this process. Results Monocyte was significantly increased the mRNA expression of MCP-1, bFGF, PDGF and IL-10 in a dose-dependent manner after incubating with OxLDL (10,15,20,25,30·mg·L-1, respectively)for 24 hours(P＜0.001). Fucoidin(50,100,150,200,250·mg·mL-1, respectively)completely inhibited OxLDL(20·mg·L-1)from inducing monocyte the mRNA expression of above proinflammatory cytokines(P＜0.001). Conclusion OxLDL can stimulate human peripheral blood monocyte to give expression to proinflammatory cytokines mRNA in a dose-dependent manner, while a peculiarly inhibitory ligand for SR-A-fucoidin has an obviously opposed role. |
| |
| Keywords: | scavenger receptor cytokine monocyte lipoprotein fucoidin atherosclerosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
