| THE CLINICAL EVALUATION OF ANGIOGENESIS INHIBITOR-20(R)-GINSENOSIDE RG_3 IN LUNG CANCER |
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| 引用本文： | 陈明伟,姚煜,石志红. THE CLINICAL EVALUATION OF ANGIOGENESIS INHIBITOR-20(R)-GINSENOSIDE RG_3 IN LUNG CANCER[J]. 西安交通大学学报(英文版), 2003, 15(2) |
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| 作者姓名： | 陈明伟 姚煜 石志红 |
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| 作者单位： | Department of Respiration，First Hospital of Xi’an Jiaotong University，Department of Respiration，First Hospital of Xi’an Jiaotong University，Department of Respiration，First Hospital of Xi’an Jiaotong University Xi’an 710061，China，Xi’an 710061，China，Xi’an 710061，China |
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| 摘 要： | GinsenosideRg3isthefirstnewChineseanti cancerdrugwithmonomestructure .Accordingtostudiesonitspharmacodynamics ,thedrugishelpfulininhibitingthe proliferationandneovasculariza tionofendothelialcellsoftumorvessels .Ifnonewvesselsarefoundinthetissues,itisdifficultfortu morcellstodiffuseortransfer.EntrustedbytheAssessmentCenterofStateDrugAdministration(SDA) ,weundertooktheexperimenttofurthertestthesafetyandeffectivenessofthedrug .Theexperimentplanwasverifiedbytheexpertgroup .MATERIALSANDM…
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THE CLINICAL EVALUATION OF ANGIOGENESIS INHIBITOR-20(R)-GINSENOSIDE RG3 IN LUNG CANCER |
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| Abstract: | Objective The aim of the study was to make a further evaluation of Ginsenoside Rg3. Methods The clinical effects of the drug on moderate and advanced lung cancer, including side effects, were observed. Results Ginsenoside Rg3 improved chemotherapy significantly. The clinical relief rate of patients treated with antiangiogenic agent 20 (R) Ginsenoside Rg3 was 36.6%, which was higher than that of the patients not treated with it (16.7%)( P <0.05). It had no significantly different effects on lung cancers of different types of tissues ( P >0.05). It provided better treatment on the cancer at early stage than that at advanced stage ( P <0.05). Moreover the living qualities of the patients were improved notably ( P <0.05). Conclusion Combined with chemotherapy, angiogenesis inhibitor 20(R) Ginsenoside Rg3 can improve clinical therapeutic efficacy and the living qualities of patients significantly. |
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| Keywords: | ginsenoside Rg3 neovascularization lung neoplasma |
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