| ALTERATION OF HB-EGF IN PSORIATIC EPIDERMIS WITH THE TREATMENT OF RETINOID ACID |
| |
| 作者姓名： | 郑焱 彭振辉 谭升顺 郗彦萍 王一理 来宝长 |
| |
| 作者单位： | Department of Dermatology，Department of Dermatology，Department of Dermatology，Department of Dermatology，Department of Immunopathology，Department of Immunopathology Second Hospital of Xi'an Jiaotong University，Xi'an 710004，China，Second Hospital of Xi'an Jiaotong University，Xi'an 710004，China，Second Hospital of Xi'an Jiaotong University，Xi'an 710004，China，Second Hospital of Xi'an Jiaotong University，Xi'an 710004，China，Medical School of Xi’an Jiaotong University，Xi’an 710061，China，Medical School of Xi’an Jiaotong University，Xi’an 710061，China |
| |
| 基金项目： | ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina (No .3 0 0 70 699) |
| |
| 摘 要： | Retinoidacid (RA)bindingtoitsnuclearre ceptorscouldexertawidevarietyofprofoundef fectsininhibitingproliferationofepidermis ,induc ingdifferentiation ,maintainingthemorphologicalfeatureofnormaltissues ,influencingblastocystde velopment,formationoforgansandtumors .Psori asisischaracterizedbyabnormalkeratinocyteprolif eration ,terminaldifferentiationanddermalangio genesis .Heparinbindingepidermalgrowthfactor likegrowthfactor (HB EGF) ,asamemberofepi dermal growthfactor (EGF )family ,hasbeenpr…
|
ALTERATION OF HB-EGF IN PSORIATIC EPIDERMIS WITH THE TREATMENT OF RETINOID ACID |
| |
| Zheng Yan,Peng Zhenhui,Tan Shengshun,Xi Yanping,Wang Yili ,Lai Baochang.ALTERATION OF HB-EGF IN PSORIATIC EPIDERMIS WITH THE TREATMENT OF RETINOID ACID[J].Academic Journal of Xi’an Jiaotong University,2003,15(1). |
| |
| Authors: | Zheng Yan Peng Zhenhui Tan Shengshun Xi Yanping Wang Yili Lai Baochang |
| |
| Institution: | 1. Department of Dermatology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China
2. Department of Immunopathology, Medical School of Xi'an Jiaotong University, Xi'an 710061,China |
| |
| Abstract: | Objective To investigate the mechanism of tazarotene in active psoriasis vulgaris. Methods HB EGF protein in active psoriatic lesions before and 10 days after the treatment of tazarotene was detected by immunohistochemistry. Results There was nearly no expression of HB EGF in psoriatic lesions (9.1%), but after the treatment by tazarotene, there was expression of HB EGF not only in basal layer (95.5%), but also focal expression in suprabasal layers of epidermis (77.3%) . Conclusion Tazarotene inhibit proliferation and induce apoptosis of keratinocytes through upregulating expression of HB EGF in psoriatic epidermis. |
| |
| Keywords: | psoriasis HB EGF suprabasal epidermis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
